Regulatory roles of phosphorylation in model and pathogenic fungi.
Regulatory roles of phosphorylation in model and pathogenic fungi.
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DOI：
10.1093/mmy/myv098
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发表时间：
2016-05
期刊：
影响因子：
2.9
通讯作者：
Kadosh D
中科院分区：
文献类型：
--
作者：
Albataineh MT;Kadosh D
在过去的20年里，我们已经取得了相当大的进展，对我们的理解如何翻译后修饰影响各种各样的生物过程，包括形态和毒力，在医学上重要的真菌。磷酸化是一种关键的分子开关和调节修饰，在控制这些过程中发挥着关键作用。在这篇文章中，我们首先提供了一个全面的和最新的概述的调节作用，这两个Ser/Thr和非Ser/Thr激酶和磷酸酶在模型和病原真菌发挥。接下来，我们讨论了目前全球方法的影响，这些方法被用来定义医学上重要的真菌中完整的磷酸化靶点（磷酸化蛋白质组）。最后，我们提供了新的见解和观点的潜在用途的关键调节激酶和磷酸酶作为目标的发展新的和更有效的抗真菌策略。
Over the past 20 years, considerable advances have been made toward our understanding of how post-translational modifications affect a wide variety of biological processes, including morphology and virulence, in medically important fungi. Phosphorylation stands out as a key molecular switch and regulatory modification that plays a critical role in controlling these processes. In this article, we first provide a comprehensive and up-to-date overview of the regulatory roles that both Ser/Thr and non-Ser/Thr kinases and phosphatases play in model and pathogenic fungi. Next, we discuss the impact of current global approaches that are being used to define the complete set of phosphorylation targets (phosphoproteome) in medically important fungi. Finally, we provide new insights and perspectives into the potential use of key regulatory kinases and phosphatases as targets for the development of novel and more effective antifungal strategies.