IS SUBSTANCE-P A PRIMARY AFFERENT NEUROTRANSMITTER FOR NOCICEPTIVE INPUT .1. ANALYSIS OF PAIN-RELATED BEHAVIORS RESULTING FROM INTRATHECAL ADMINISTRATION OF SUBSTANCE-P AND 6 EXCITATORY COMPOUNDS
IS SUBSTANCE-P A PRIMARY AFFERENT NEUROTRANSMITTER FOR NOCICEPTIVE INPUT .1. ANALYSIS OF PAIN-RELATED BEHAVIORS RESULTING FROM INTRATHECAL ADMINISTRATION OF SUBSTANCE-P AND 6 EXCITATORY COMPOUNDS
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DOI：
10.1016/0006-8993(88)90080-7
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发表时间：
1988-07-12
期刊：
影响因子：
2.9
通讯作者：
MAYER, DJ
中科院分区：
文献类型：
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作者：
FRENK, H;BOSSUT, D;MAYER, DJ
鞘内（i.t）注射P物质（SP），辣椒素，红藻氨酸，印防己毒素，士的宁，吗啡，L-谷氨酸在大鼠诱导有节奏的抓挠运动与后肢，咬，并与这些化合物，发声和肌阵挛性抽搐。虽然叮咬针对的是与注射部位对应的皮节，但抓挠针对的是前皮节。推测疼痛的化学刺激产生的皮肤和皮下应用辣椒素或醋酸从来没有引起抓挠。发声从来没有引起的SP。印防己毒素和吗啡，它与肌阵挛性抽搐，而不是与抓和/或咬。这些发现表明，抓挠（a）与疼痛无关，（B）当由i.t.施用上述化合物不是由伤害性初级传入突触的激活引起的。
Intrathecal (i.t) injection of substance P (SP), capsaicin, kainic acid, picrotoxin, strychnine, morphine, and L-glutamic acid in rats induced rhythmic scratching movements with the hindlimbs, biting, and, with some of these compounds, vocalization and myoclonic twitches. Although biting was directed to the dermatone corresponding to the injection site, scratching was aimed at anterior dermatomes. Presumably painful chemical stimulation produced by cutaneous and subcutaneous application of capsaicin or acetic acid never elicited scratching. Vocalization was never elicited by SP. When vocalization occurred following i.t. picrotoxin and morphine, it was correlated with myoclonic twitches rather than with scratching and/or biting. These findings indicate that scratching (a) is not pain-related and, (b) when elicited by the i.t. administration of the compounds listed above, does not result from activation of nociceptive primary afferent synapses.