Interactive Effects of Oligofructose and Obesity Predisposition on Gut Hormones and Microbiota in Diet-Induced Obese Rats
Interactive Effects of Oligofructose and Obesity Predisposition on Gut Hormones and Microbiota in Diet-Induced Obese Rats
复制标题
DOI：
10.1002/oby.21017
复制
发表时间：
2015-04-01
期刊：
影响因子：
6.9
通讯作者：
Sharkey, Keith A.
中科院分区：
文献类型：
--
作者：
Cluny, Nina L.;Eller, Lindsay K.;Sharkey, Keith A.
低聚果糖（OFS）是一种益生元，通过改变肠道饱腹激素和微生物群来减少能量摄入和脂肪量。OFS的影响可能因肥胖倾向而异。本研究的目的是检查OFS在饮食诱导的肥胖（DIO）和饮食抵抗（DR）rats.MethodsAdult，雄性DIO，和DR大鼠的效果随机分为：高脂肪/高蔗糖（HFS）饮食或HFS饮食+10%OFS 6周。测量了身体组成、食物摄入、肠道微生物群、血浆肠道激素和结状神经节中大麻素CB 1受体的表达。
ObjectiveOligofructose (OFS) is a prebiotic that reduces energy intake and fat mass via changes in gut satiety hormones and microbiota. The effects of OFS may vary depending on predisposition to obesity. The aim of this study was to examine the effect of OFS in diet-induced obese (DIO) and diet-resistant (DR) rats.MethodsAdult, male DIO, and DR rats were randomized to: high-fat/high-sucrose (HFS) diet or HFS diet+10% OFS for 6 weeks. Body composition, food intake, gut microbiota, plasma gut hormones, and cannabinoid CB1 receptor expression in the nodose ganglia were measured.ResultsOFS reduced body weight, energy intake, and fat mass in both phenotypes (P