Smoking cessation and mortality from cardiovascular disease among japanese men and women - The JACC Study
Smoking cessation and mortality from cardiovascular disease among japanese men and women - The JACC Study
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DOI：
10.1093/aje/kwi027
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发表时间：
2005-01-15
影响因子：
5
通讯作者：
Tamakoshi, A
中科院分区：
文献类型：
--
作者：
Iso, H;Date, C;Tamakoshi, A
为了研究戒烟对亚洲人心血管疾病死亡率的影响，作者对94,683名年龄在40-79岁之间的日本人（41,782名男性和52,901名女性）进行了一项为期10年的前瞻性队列研究，这些人是日本癌症风险评估合作队列研究（JACC研究）的一部分。在1989-1990年至1999年941,043人年的随访期间，男性中有698人死于中风，348人死于冠心病，1,555人死于心血管疾病，女性中分别有550人、199人和1,155人死亡。对于男性，目前吸烟者与从不吸烟者相比，中风的多变量相对危险度为1.39(95%可信区间（CI）： 1.13, 1.70)，冠心病的多变量相对危险度为2.51 (95% CI: 1.79, 3.51)，总心血管疾病的多变量相对危险度为1.60 （95% CI: 1.39, 1.84）。女性的相对危险度分别为1.65 （95% CI: 1.21, 2.25）、3.35 （95% CI: 2.23, 5.02）和2.06 (95% CI: 1.69, 2.51)， 40-64岁人群的超额危险度大于老年人。戒烟后2年内冠心病和总心血管疾病的风险下降，2-4年后总中风的风险下降。对于每个终点和40-64岁和65-79岁两个年龄亚组，戒烟的大部分益处发生在戒烟后10-14年。研究结果表明，日本人在任何年龄戒烟对预防心血管疾病都很重要。
To examine the effect of smoking cessation on cardiovascular disease mortality in Asians, the authors conducted a 10-year prospective cohort study of 94,683 Japanese (41,782 men and 52,901 women) aged 40-79 years who were part of the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). During 941,043 person-years of follow-up between 1989-1990 and 1999, 698 deaths from stroke, 348 from coronary heart disease, and 1,555 from total cardiovascular disease occurred in men and 550, 199, and 1,155, respectively, in women. For men, the multivariate relative risks for current smokers compared with never smokers were 1.39 (95% confidence interval (CI): 1.13, 1.70) for stroke, 2.51 (95% CI: 1.79, 3.51) for coronary heart disease, and 1.60 (95% CI: 1.39, 1.84) for total cardiovascular disease. The respective relative risks for women were 1.65 (95% CI: 1.21, 2.25), 3.35 (95% CI: 2.23, 5.02), and 2.06 (95% CI: 1.69, 2.51), with larger excess risks for persons aged 40-64 years than for older persons. The risk decline after smoking cessation occurred for coronary heart disease and total cardiovascular disease within 2 years and for total stroke after 2-4 years. For each endpoint and in both age subgroups of 40-64 and 65-79 years, most of the benefit of cessation occurred after 10-14 years following cessation. Findings imply the importance of smoking cessation at any age to prevent cardiovascular disease in Japanese.