Multiple mechanisms of withdrawal from opioid drugs.
Multiple mechanisms of withdrawal from opioid drugs.
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阿片类药物戒断的多种机制。
DOI：
10.1146/annurev.ne.07.030184.002303
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发表时间：
1984
影响因子：
13.9
通讯作者：
Krystal,JH
中科院分区：
文献类型：
--
作者：
RedmondJr,DE;Krystal,JH
综述了阿片戒断综合征期间的生化变化和药理学效应的文献，重点介绍了不同戒断现象的生化机制之间明显重叠的领域。这些区域可能为可能的“最终共同路径”提供线索。本文讨论了阿片依赖过程中内源性阿片受体改变的证据，一些细胞内调节剂的参与，6种神经递质改变的证据，以及阿片戒断过程中可能影响细胞机制的一些行为和环境因素。从内源性阿片分布和活性到人体可乐定的抗戒断作用，大量证据表明，中枢去甲肾上腺素系统，包括蓝斑核，可能对进一步研究经典阿片戒断综合征的生物化学很重要。在阿片戒断过程中，一些已知的细胞内、受体和神经递质机制的参与可以追溯到与去甲肾上腺素能神经元的相互作用。（PsycInfo数据库记录(c) 2020 APA，版权所有）
Reviews the literature on the biochemical changes and pharmacologic effects during the opiate abstinence syndrome, focusing on areas where overlap is apparent between different biochemical mechanisms of withdrawal phenomena. These areas may provide clues to possible" final common pathways." The evidence for alterations of endogenous opiate receptors during opiate dependence, the involvement of some intracellular modulators, the evidence for alterations in 6 neurotransmitters, and some behavioral and environmental factors in opioid withdrawal that may have implications for cellular mechanisms are discussed. Considerable portions of the evidence, from endogenous opioid distributions and activities to the antiwithdrawal effects of clonidine in human Ss, suggest that central norepinephrine systems, including the nucleus locus coeruleus, may be important for further studies of the biochemistry of the classical opiate withdrawal syndrome. Involvement of several known intracellular, receptor, and neurotransmitter mechanisms in opiate withdrawal may be traced to interactions with noradrenergic neurons.(PsycInfo Database Record (c) 2020 APA, all rights reserved)