Application of zebrafish oculomotor behavior to model human disorders
Application of zebrafish oculomotor behavior to model human disorders
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DOI：
10.1515/rns.2011.003
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发表时间：
2011-01-01
影响因子：
4.1
通讯作者：
Neuhauss, Stephan C. F.
中科院分区：
文献类型：
--
作者：
Maurer, Colette M.;Huang, Ying-Yu;Neuhauss, Stephan C. F.
为了确保高敏锐度的视力，眼球运动必须由眼科系统以惊人的精度控制。许多人类疾病可以导致异常的眼球运动，通常是称为眼球震颤的无意识振荡眼球运动类型。这种眼球震颤可能是先天性的（婴儿）或后天获得的。虽然由此产生的眼球运动的特点是很好的，只有很少的信息有关的根本病因。部分原因是缺乏适当的动物模型。在这篇综述文章中，我们描述了如何斑马鱼与其快速成熟的视觉系统可以用来模拟眼病。我们比较了人类和斑马鱼眼动的特点和评估。我们描述的斑马鱼突变颠茄，它具有非交叉的光纤，是一个特别翔实的模型，为人类oculonnotor赤字的oculablity属性。这种突变体显示出反向视动反应，自发振荡，密切模仿人类先天性眼球震颤和异常运动行为与圆形向量。
To ensure high acuity vision, eye movements have to be controlled with astonishing precision by the oculomotor system. Many human diseases can lead to abnormal eye movements, typically of the involuntary oscillatory eye movements type called nystagmus. Such nystagmus can be congenital (infantile) or acquired later in life. Although the resulting eye movements are well characterized, there is only little information about the underlying etiology. This is in part owing to the lack of appropriate animal models. In this review article, we describe how the zebrafish with its quick maturing visual system can be used to model oculomotor pathologies. We compare the characteristics and assessment of human and zebrafish eye movements. We describe the oculomotor properties of the zebrafish mutant belladonna, which has non-crossing optical fibers, and is a particularly informative model for human oculonnotor deficits. This mutant displays a reverse optokinetic response, spontaneous oscillations that closely mimic human congenital nystagmus and abnormal motor behavior linked to circular vection.