Role of Borage Seed Oil and Fish Oil with or without Turmeric and Alpha-Tocopherol in Prevention of Cardiovascular Disease and Fatty Liver in Rats
Role of Borage Seed Oil and Fish Oil with or without Turmeric and Alpha-Tocopherol in Prevention of Cardiovascular Disease and Fatty Liver in Rats
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DOI：
10.5650/jos.ess18064
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发表时间：
2018-12-01
影响因子：
1.5
通讯作者：
Moawa, Hosam F.
中科院分区：
文献类型：
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作者：
Al-Okbi, Sahar Y.;El-qousy, Salah M.;Moawa, Hosam F.
本研究的目的是研究通过琉璃苣油（B）和鱼油（F）与或不与姜黄（T）和α-生育酚（TC）的干预来预防血脂异常、氧化应激、炎症和脂肪肝等心血管疾病的危险因素。在两种油中评估脂肪酸，而在姜黄中测定姜黄素。大鼠分为：第一组饲喂平衡饮食，指定为正常对照（NC），第二组饲喂血脂异常和脂肪性肝炎（DS）诱导剂饮食，代表DS对照组，第3-6组饲喂DS诱导剂饮食，每日口服B、B+T+TC、F和F+T+TC;分别持续5周。评估肝脏脂肪和血浆脂质谱、氧化应激和炎症生物标志物以及肝脏和心脏组织病理学。结果表明，B中γ-亚麻酸含量为21.01%. F中二十碳五烯酸含量为22.768%，二十二碳六烯酸含量为13.574%。总姜黄素为4.63 mg/g姜黄。与NC相比，DS对照组显示出显著的血脂异常、丙二醛（MDA）、肿瘤坏死因子-α和肝脏脂肪升高，总抗氧化能力（TAC）显著降低。不同的治疗产生了显着改善的所有参数和组织病理学。F组在改善肝组织病理学改变方面上级优于B组，而B组在提高TAC方面更有效。与B + T + TC相比，B更有希望改善血脂谱和肝脏脂肪，而后者在改善MDA和肝脏组织病理学方面优于上级。鱼油比F+TC+T更有效，除了TAC和高密度脂蛋白胆固醇在添加TC和T后得到更好的改善。结论：琉璃苣和鱼油加或不加抗氧化剂对心血管疾病和脂肪肝均有不同程度的保护作用。
The aim of the present research was to Study the prevention of dyslipidemia, oxidative stress, inflammation and fatty liver as risk factors for cardiovascular disease via intervention by borage oil (B) and fish oil (F) with or without turmeric (T) and alpha-tocopherols (TC). Fatty acids were assessed in both oils while curcuminoids were determined in turmeric. Rats were divided into; first group fed on balanced diet and designated as normal control (NC), second fed on dyslipidemic and steatohepatitis (DS) inducer diet which represented the DS control group and groups 3-6 fed on DS inducer diet with daily oral administration of B, B+T+TC, F and F+T+TC; respectively for 5 weeks. Liver fat and plasma lipid profile, oxidative stress and inflammatory biomarker and liver and heart histopathology were assessed. Results showed gamma linolenic to be 21.01% in B. F contained eicosapentaenoic as 22.768% and docosahexaenoic acid as 13.574%. Total curcuminoids were 4.63 mg/g turmeric. The DS control group showed significant dyslipidemia, elevated malondialdehyde (MDA), tumor necrosis factor-alpha and liver fat with significant reduction in total antioxidant capacity (TAC) compared to NC. The different treatments produced significant improvement in all the parameters and histopathology. F was superior to B in ameliorating liver histopathological changes while B was more efficient in elevating TAC. B was more promising in improving lipid profile and liver fat compared to B + T + TC, while the latter was superior in improving MDA and liver histopathology. Fish oil was more efficient than F+TC+T except for TAC and high density lipoprotein cholesterol which were more improved on addition of TC and T. Conclusion: Borage and fish oil with or without antioxidants protect from cardiovascular and fatty liver diseases with variable degrees.