Impact of the Low- to High-Density Lipoprotein Cholesterol Ratio on Composition of Angiographically Ambiguous Left Main Coronary Artery Plaque
Impact of the Low- to High-Density Lipoprotein Cholesterol Ratio on Composition of Angiographically Ambiguous Left Main Coronary Artery Plaque
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DOI：
10.1253/circj.cj-11-0019
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发表时间：
2011-08-01
影响因子：
3.3
通讯作者：
Murohara, Toyoaki
中科院分区：
文献类型：
--
作者：
Kurebayashi, Nobutake;Yoshikawa, Daiji;Murohara, Toyoaki
背景资料：高的低密度脂蛋白胆固醇（LDL-C）与高密度脂蛋白胆固醇（HDL-C）比值与心脏事件相关，而左冠状动脉主干（LMCA）被认为是动脉粥样硬化斑块积聚的重要靶点。本研究的目的是探讨LDL-C/HDL-C比值和LMCA plaque.Methods和Results的组织成分的特点之间的关系：120例连续稳定型心绞痛患者接受慢性他汀类药物治疗进行经皮冠状动脉介入治疗的左冠状动脉。我们前瞻性地对他们的LMCA进行了背向散射积分（IB）血管内超声（NUS），并评估了组织特性。根据LDL-C/HDL-C比值中位数（2.4）分为高LDL-C/HDL-C比值（>2.4）组（n=60）和低LDL-C/HDL-C比值（
Background: A high low-density lipoprotein cholesterol (LDL-C) to a high-density lipoprotein cholesterol (HDL-C) ratio is associated with cardiac events, while the left main coronary artery (LMCA) is considered to be an important target of atherosclerotic plaque accumulation. This aim of the present study was to investigate the relationship between a LDL-C/HDL-C ratio and the characteristics of tissue components of LMCA plaque.Methods and Results: One-hundred-twenty consecutive patients with stable angina pectoris who received chronic statin treatment underwent percutaneous coronary intervention for the left coronary artery. We prospectively performed integrated backscatter (IB) intravascular ultrasound (NUS) to their LMCAs and evaluated the tissue characteristics. According to the median value of their LDL-C/HDL-C ratios (2.4), they were divided into 2 groups [high LDL-C/HDL-C ratio (>2.4) (n=60) or low LDL-C/HDL-C ratio (