Maternal smoking in pregnancy, adult adiposity and other risk factors for cardiovascular disease
Maternal smoking in pregnancy, adult adiposity and other risk factors for cardiovascular disease
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DOI：
10.1016/j.atherosclerosis.2010.03.015
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发表时间：
2010-08-01
期刊：
影响因子：
5.3
通讯作者：
Thomas, C.
中科院分区：
文献类型：
--
作者：
Power, C.;Atherton, K.;Thomas, C.
目的：要建立母亲在怀孕期间吸烟是否与成年中期心血管疾病（CVD）的危险因素，以及是否协会解释产后influencs.Methods：参与者是8815名男性和女性在1958年英国出生队列，在45岁的心血管疾病危险因素的数据。母亲吸烟记录在birth.Results：吸烟者的后代有较高的成人BMI，腰围，血压，HbA1c和甘油三酯的平均比后代的非吸烟者，女性有较低的HDL胆固醇水平。总胆固醇与母亲吸烟无关。在对出生后的影响进行调整后，除了BMI和腰围之外，两者之间的关联被消除了：吸烟者后代的BMI平均比不吸烟者后代高0.83 kg/m2，腰围高1.8 cm。平均体重指数和腰围随着母亲吸烟的数量而增加，但在母亲在怀孕前或怀孕早期戒烟的后代中并没有升高。结论：在子宫内暴露于烟草的成年人在成年中期有更不利的心血管疾病风险，这似乎反映了出生后影响的终生积累;而他们较高的BMI和中心性肥胖可能部分归因于宫内机制。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Objective: To establish whether maternal smoking in pregnancy is associated with risk factors for cardiovascular disease (CVD) in mid-adulthood and whether associations are explained by postnatal influences.Methods: Participants were 8815 men and women in the 1958 British birth cohort, with data on CVD risk factors measured at 45 y. Maternal smoking was recorded at birth.Results: Offspring of smokers had a higher adult BMI, waist circumference, blood pressure, HbA1c and triglycerides on average than offspring of non-smokers; females had lower HDL cholesterol levels. Total cholesterol was unrelated to maternal smoking. Associations were abolished after adjustment for postnatal influences across life, except for BMI and waist circumference: offspring of smokers had a BMI greater by 0.83 kg/m(2) on average than offspring of non-smokers and a 1.8cm larger waist circumference. Mean BMI and waist circumference increased with number of cigarettes that the mother smoked, but were not elevated in offspring whose mother had quit smoking before or early in pregnancy.Conclusions: Adults exposed to tobacco in utero had a more adverse CVD risk profile in mid-adulthood which appeared to reflect a lifetime accumulation of postnatal influences; whereas their higher BMI and central adiposity may be due in part to intrauterine mechanisms. (C) 2010 Elsevier Ireland Ltd. All rights reserved.