Critical determinants of metastasis
Critical determinants of metastasis
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DOI：
10.1006/scbi.2001.0416
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发表时间：
2002-04-01
影响因子：
14.5
通讯作者：
Fidler, IJ
中科院分区：
文献类型：
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作者：
Fidler, IJ
癌症死亡的主要原因是由于对常规疗法有抗性的转移。有几个原因导致转移瘤治疗失败。首先，肿瘤在生物学上是异质的，并且包含具有不同血管生成、侵袭和转移特性的细胞亚群。第二，转移过程选择了一小群细胞，这些细胞预先存在于母体肿瘤中。第三，也可能是治疗的最大障碍，是转移的结果取决于转移细胞与肿瘤细胞篡夺的稳态机制的多重相互作用（“串扰”）。最近的数据表明，器官微环境可以影响肿瘤的生长、侵袭和对化疗的反应。因此，转移的治疗应该针对转移性肿瘤细胞和促进转移的稳态因子。
The major cause of death from, cancer is due to metastases that are resistant to conventional therapies. Several reasons account for the failure to treat metastases. First, neoplasms are biologically heterogeneous and contain subpopulations of cells with different angiogenic, invasive, and metastatic properties. Second, the process of metastasis selects for a small subpopulation of cells that preexist within a parental neoplasm. Third, and perhaps the greatest obstacle for therapy, is that the outcome of metastasis depends on multiple interactions ('cross-talk') of metastatic cells with homeostatic mechanisms which the tumor cells usurp. Most recent data demonstrate that the organ microenvironment can influence the growth, invasion, and response of metastases to chemotherapy. Therapy of metastasis should therefore be targeted against both the metastatic tumor cells and the homeostatic factors that promote metastasis.