The Evaluation of Immunohistochemical Markers and Thymic Cortical Microenvironmental Cells in Distinguishing Thymic Carcinoma from Type B3 Thymoma or Lung Squamous Cell Carcinoma
The Evaluation of Immunohistochemical Markers and Thymic Cortical Microenvironmental Cells in Distinguishing Thymic Carcinoma from Type B3 Thymoma or Lung Squamous Cell Carcinoma
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DOI：
10.3960/jslrt.53.9
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发表时间：
2013-06-01
影响因子：
1.5
通讯作者：
Takahashi, Kiyoshi
中科院分区：
文献类型：
--
作者：
Hayashi, Atsushi;Fumon, Takumi;Takahashi, Kiyoshi
胸腺癌（TC）通常很难与累及前纵隔的B3型胸腺瘤和肺鳞状细胞癌（LSCC）鉴别。本研究评价了免疫组织化学标记物包括c-Kit、CD 5、葡萄糖转运蛋白-1（GLUT-1）、claudin-1（CLDN-1）、胸腺蛋白酶体β 5 t、p53和Ki-67（MIB-1）以及胸腺皮质环境标记物细胞的有用性，皮质胸腺细胞（c-Thy）和胸腺皮质树枝状巨噬细胞（TCDM）在区分胸腺癌（TC）中的作用B3型胸腺瘤或肺鳞状细胞癌（L-SCC）使用17例B3型胸腺瘤、18例TC和12例L-SCC。结果表明，c-Kit和CD 5是TC的重要标志物，而GLUT-1、CLDN-1、p53和Ki-67则不是TC的重要标志物。胸腺皮质微环境标记细胞，尤其是TCDMs，和胸腺皮质上皮细胞标记β 5 t也可用于区分TC和B3型胸腺瘤。虽然这些标记物中没有一个在单独使用时足以进行区分，但c-Kit、CD 5、β 5 t胸腺皮质环境标记细胞、c-Thys和TCDM的多个使用因此可能导致TC和B3型胸腺瘤或L-SCC之间的正确区分。
Thymic carcinoma (TC) is often very difficult to distinguish from type B3 thymoma and lung squamous cell carcinoma (LSCC) involving the anterior mediastinum. The present study evaluated the usefulness of immunohistochemical markers including c-Kit, CD5, glucose transporter-1 (GLUT-1), claudin-1 (CLDN-1), thymoproteasome beta 5t, p53 and Ki-67 (MIB-1) and thymic cortical environmental marker cells, cortical thymocytes (c-Thy) and thymic cortical dendritic macrophages (TCDMs) in distinguishing thymic carcinoma (TC) from type B3 thymoma or lung squamous cell carcinoma (L-SCC) using 17 cases of type B3 thymoma, 18 cases of TC and 12 cases of L-SCC. The results indicated that c-Kit and CD5 are very useful markers for TC, while GLUT-1, CLDN-1, p53 and Ki-67 are not. Thymic cortical microenvironmental marker cells, especially TCDMs, and thymic cortical epithelial cell-marker beta 5t are also useful for distinguishing TC from type B3 thymoma. Although none of these markers are adequate for making a distinction when used alone, the plural use of c-Kit, CD5, beta 5t thymic cortical environmental marker cells, c-Thys and TCDMs may therefore lead to a correct distinction between TC and type B3 thymoma or L-SCC.