Reactive type II pneumocytes in bronchoalveolar lavage fluid
Reactive type II pneumocytes in bronchoalveolar lavage fluid
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DOI：
10.1159/000326411
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发表时间：
2004-07-01
期刊：
影响因子：
1.8
通讯作者：
Drent, M
中科院分区：
文献类型：
--
作者：
Linssen, KCFM;Jacobs, JA;Drent, M
目的：为了评估反应性II型肺细胞（RPII）在支气管肺泡灌洗液（BAL）的各种肺disorders.Study设计：收集的BAL液样本中的患病率进行了筛选的存在RPII的五月GriinwaldGiemsa染色的细胞离心制剂。BAL液样本与无RPII进行了比较方面的患病率，相关的临床诊断和细胞学findings.RESULTS：RPII一般是大细胞与高的核：胞质比和深蓝色染色，空泡化的细胞质。多数RPII发生在粘连的细胞群中，空泡趋于融合。与RPII相关的细胞学结果是泡沫状肺泡巨噬细胞、活化的淋巴细胞和浆细胞。在纳入的433份BAL液样本中，94份（21.7%）存在RPII。全身炎症反应综合征和肺泡出血患者的患病率最高。此外，呼吸机相关性肺炎、卡氏肺孢子虫肺炎、外源性过敏性肺泡炎和药物性肺部疾病更容易发生RPII。结论：RPII在20%的支气管肺泡灌洗液标本中普遍存在。它们主要与急性肺损伤有关，而在结节病中未观察到。
OBJECTIVE: To evaluate the prevalence of reactive type II pneumocytes (RPII) in bronchoalveolar lavage (BAL) fluid samples obtained from patients with various pulmonary disorders.STUDY DESIGN: Consecutive BAL fluid samples were screened for the presence of RPII on May-GriinwaldGiemsa-stained cytocentrifuge preparations. BAL fluid samples with and without RPII were compared with regard to prevalence, associated clinical diagnoses and cytologic findings.RESULTS: RPII were generally large cells with a high nuclear:cytoplasmic ratio and deeply blue-stained, vacuolated cytoplasm. Most RPII occurred in cohesive cell groups, and the vacuoles tended to be confluent. Cytologic findings associated with RPII were foamy alveolar macrophages, activated lymphocytes and plasma cells. RPII were present in 94 (21.7%) of 433 included BAL fluid samples. The highest prevalences were noted in patients with systemic inflammatory response syndrome and alveolar hemorrhage. In addition, RPII tended to occur more frequently in ventilator-associated pneumonia, Pneumocystis carinii pneumonia, extrinsic allergic alveolitis and drug-induced pulmonary disorders. In contrast, RPII were not observed in BAL fluid samples obtained from patients with sarcoidosis.CONCLUSION: RPII were prevalent in about 20% of BAL fluid specimens. They were associated mainly with conditions of acute lung injury and not observed in sarcoidosis.