Multifunctional hybrid magnetite nanoparticles with pH-responsivity, superparamagnetism and fluorescence
Multifunctional hybrid magnetite nanoparticles with pH-responsivity, superparamagnetism and fluorescence
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DOI：
10.1002/pi.3081
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发表时间：
2011-09
影响因子：
3.2
通讯作者：
Lilin Zhou;Z. Cai;Jinying Yuan;Yan Kang;Weizhong Yuan;D. Shen
中科院分区：
文献类型：
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作者：
Lilin Zhou;Z. Cai;Jinying Yuan;Yan Kang;Weizhong Yuan;D. Shen
合成了具有pH响应性、超顺磁性和荧光性的多功能杂化纳米粒子Fe3O4@聚[(2-二甲氨基)甲基丙烯酸乙酯]-嵌段-聚(甲基丙烯酸2-羟乙酯)-接枝咔唑，用于靶向药物递送和释放。纳米颗粒具有由透射电子显微镜测定的核-壳结构、由流体动力学半径分析测定的pH响应性、由振动样品磁力测定测定的超顺磁性以及由荧光光谱和荧光显微镜测定的荧光。模型药物黄体酮的释放行为表明，通过改变环境pH值可以有效控制释放速率。多功能纳米颗粒可广泛应用于靶向药物递送和释放，并且通过荧光，它们可以作为有效的示踪剂来记录磁性靶向路线。版权所有© 2011 中国化工学会
Multifunctional hybrid nanoparticles, Fe3O4@poly[(2-dimethylamino)ethyl methacrylate]-block-poly(2-hydroxyethyl methacrylate)-graft-carbazole, with pH-responsivity, superparamagnetism and fluorescence for targeted drug delivery and release have been synthesized. The nanoparticles have a core-shell structure as determined from transmission electron microscopy, pH-responsivity as determined from hydrodynamic radius analysis, superparamagnetism as determined from vibrating sample magnetometry and fluorescence as determined from fluorescence spectroscopy and fluorescence microscopy. The release behavior of model drug progesterone indicates that the release rate can be effectively controlled by altering the pH of the environment. The multifunctional nanoparticles could be applied extensively in targeted drug delivery and release, and with fluorescence they can serve as efficient tracers to record magnetic targeting routes. Copyright © 2011 Society of Chemical Industry