Functional Organization of the Fusiform Gyrus Revealed with Connectivity Profiles
Functional Organization of the Fusiform Gyrus Revealed with Connectivity Profiles
复制标题
通过连接配置文件揭示梭状回的功能组织
DOI：
10.1002/hbm.23222
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发表时间：
2016-08-01
影响因子：
4.8
通讯作者：
Jiang, Tianzi
中科院分区：
文献类型：
--
作者：
Zhang, Wen;Wang, Jiaojian;Jiang, Tianzi
在与物体记忆相关的腹侧视觉流中，人类梭状回（FG）在高水平视觉/认知功能中起着关键作用，它在地形上连接纹状体皮层和下颞叶。然而，虽然有许多以前的调查不同的功能模块内的FG，整个FG在其完整的功能异质性的功能组织尚未建立。在目前的研究中，一个可复制的功能组织的FG的基础上不同的解剖连接模式被确定。使用扩散张量成像将FG分成内侧（FGm）、外侧（FGl）和前部（FGa）区域。我们从静息态全脑功能连接模式和功能子网络参与的角度验证了这种组织方案的合理性。我们发现佐证支持这三个不同的模块，并建议，FGm作为一个过渡区，结合多种刺激，FGl是负责分类识别，和FGa参与语义理解。这些研究结果支持两个组织功能的腹侧颞回过渡，后/前方向的视觉/语义处理，和媒体/横向方向的高层次视觉处理。我们的研究结果可能有助于更详细的研究，在未来的人类FG。(C)2016 Wiley Periodicals，Inc.
Within the object recognition-related ventral visual stream, the human fusiform gyrus (FG), which topographically connects the striate cortex to the inferior temporal lobe, plays a pivotal role in high-level visual/cognitive functions. However, though there are many previous investigations of distinct functional modules within the FG, the functional organization of the whole FG in its full functional heterogeneity has not yet been established. In the current study, a replicable functional organization of the FG based on distinct anatomical connectivity patterns was identified. The FG was parcellated into medial (FGm), lateral (FGl), and anterior (FGa) regions using diffusion tensor imaging. We validated the reasonability of such an organizational scheme from the perspective of resting-state whole brain functional connectivity patterns and the involvement of functional subnetworks. We found corroborating support for these three distinct modules, and suggest that the FGm serves as a transition region that combines multiple stimuli, the FGl is responsible for categorical recognition, and the FGa is involved in semantic understanding. These findings support two organizational functional transitions of the ventral temporal gyrus, a posterior/anterior direction of visual/semantic processing, and a media/lateral direction of high-level visual processing. Our results may facilitate a more detailed study of the human FG in the future. (C) 2016 Wiley Periodicals, Inc.