Acquisition and maturation of oral microbiome throughout childhood: An update
Acquisition and maturation of oral microbiome throughout childhood: An update
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发表时间：
2014-07
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通讯作者：
B. Sampaio-Maia;Filipa Monteiro-Silva
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作者：
B. Sampaio-Maia;Filipa Monteiro-Silva
随着测序和大规模基因组分析等新微生物技术的发展，传统微生物学概念正在被更新。进入新千年以来，出现了许多有关口腔微生物组的新信息。本修订版概述了有关新生儿口腔微生物群落获取以及该微生物群向成年演化的新知识。在整个童年时期，口腔微生物负荷增加，但微生物多样性减少。最初的殖民者与交付类型、人际关系、居住环境有关。这些第一批殖民者似乎影响了随后的殖民，这将导致成年期更加复杂和稳定的生态系统。因此，这些早期口腔微生物群落在成人口腔微生物群的发育中发挥着重要作用，并且可能代表人类生命早期阶段致病性和保护性微生物的来源。强调了这些知识对牙儿科日常临床实践的影响。
Traditional microbiology concepts are being renewed since the development of new microbiological technologies, such as, sequencing and large-scale genome analysis. Since the entry into the new millennium, a lot of new information has emerged regarding the oral microbiome. This revision presents an overview of this renewed knowledge on oral microbial community acquisition in the newborn and on the evolution of this microbiome to adulthood. Throughout childhood, the oral microbial load increases, but the microbial diversity decreases. The initial colonizers are related to the type of delivery, personal relationships, and living environment. These first colonizers seem to condition the subsequent colonization, which will lead to more complex and stable ecosystems in adulthood. These early oral microbial communities, therefore, play a major role in the development of the adult oral microbiota and may represent a source of both pathogenic and protective microorganisms in a very early stage of human life. The implications of this knowledge on the daily clinical practice of odontopediatrics are highlighted.