Racial and ethnic differences in presentation, etiology, and outcomes of acute liver failure in the United States.
Racial and ethnic differences in presentation, etiology, and outcomes of acute liver failure in the United States.
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DOI：
10.1016/j.cgh.2009.05.029
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Acute Liver Failure Study Group
中科院分区：
文献类型：
--
作者：
Forde KA;Reddy KR;Troxel AB;Sanders CM;Lee WM;Acute Liver Failure Study Group
在慢性肝病患者中，RACE对肝移植的发生率和患者移植后的存活率有一定的影响。然而，种族和民族如何影响急性肝功能衰竭(ALF)患者的表现、病因和预后尚不清楚。利用ALF研究小组数据库进行了一项回溯性队列研究，以评估ALF受试者中种族和民族之间的差异。在1998年1月至2006年3月期间登记的927名受试者(白人81.8%，黑人12.8%，亚裔5.4%)中，年龄、性别和教育水平在不同群体中具有可比性。在精神疾病的患病率和药物使用方面发现了差异。在ALF的病因方面，种族也不同。白人出现对乙酰氨基酚中毒的频率更高(51%比27%，P<；0.001)。到第21天，228名白人(30%)、46名黑人(39%)和11名亚洲人(22%)死亡。在调整包括ALF病因、脑病程度、年龄、性别、入院化验值和地区在内的潜在混杂因素后，总体死亡率没有统计学意义上的差异。在亚洲人和拉美裔人中，肝移植的几率更高，但在调整了上述混杂因素后，这一发现在亚洲人中有所减弱(调整后的OR分别为1.50；95%CI分别为0.72~3.13和1.89；95%CI为1.08~3.30)。在ALF患者中，除了西班牙裔的移植外，种族和民族之间的存活率或肝移植比率没有显著差异。
In patients with chronic liver disease, race plays a role in rate of liver transplantation and patient survival after transplantation. It is not known however how race and ethnicity influence the presentation, etiology and outcomes in patients with acute liver failure (ALF). A retrospective cohort study was conducted utilizing the ALF Study Group database to assess differences between racial and ethnic groups in subjects with ALF. In the cohort of 927 subjects (81.8% white, 12.8% black and 5.4% Asian), enrolled between January 1998 and March 2006, age, gender and level of education were comparable among the groups. Differences were found in the prevalence of psychiatric illness and the use of medications. Racial groups also differed with respect to etiology of ALF. Whites presented more frequently with acetaminophen toxicity (51% vs. 27%, P <0.001). By day 21, 228 (30%) whites, 46 (39%) blacks, and 11 (22%) Asians had died. There were no statistically significant differences found in overall mortality after adjustment for potential confounders including etiology of ALF, degree of encephalopathy, age, gender, admission laboratory values and region. The odds of liver transplantation were higher among Asians and Hispanics however this finding was attenuated in Asians after adjustment for the above confounders (adjusted OR 1.50; 95% CI 0.72-3.13 and 1.89; 95% CI 1.08 – 3.30, respectively). In patients with ALF, there were no significant differences in survival or rate of liver transplantation among racial and ethnic groups except for transplantation in Hispanics.
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影响因子：
9.8
作者：
Cheung, RC;Currie, S;Wright, TL
通讯作者：
Wright, TL
DOI：
10.1002/lt.500040606
发表时间：
1998-11-01
期刊：
LIVER TRANSPLANTATION AND SURGERY
影响因子：
--
作者：
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通讯作者：
Bynon, S
影响因子：
9.8
作者：
Ananthakrishnan, Ashwin N.;Saeian, Kia
通讯作者：
Saeian, Kia
影响因子：
3.7
作者：
KAPLAN, EL;MEIER, P
通讯作者：
MEIER, P
影响因子：
4.3
作者：
Trooskin, Stacey B.;Navarro, Victor J.;Rossi, Simona
通讯作者：
Rossi, Simona