SEQUENCE HOMOLOGY AND MORPHOLOGIC SIMILARITY OF HTLV-III AND VISNA VIRUS, A PATHOGENIC LENTI-VIRUS
SEQUENCE HOMOLOGY AND MORPHOLOGIC SIMILARITY OF HTLV-III AND VISNA VIRUS, A PATHOGENIC LENTI-VIRUS
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DOI：
10.1126/science.2981428
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
GILDEN, RV
中科院分区：
文献类型：
--
作者：
GONDA, MA;WONGSTAAL, F;GILDEN, RV
对人嗜T淋巴细胞逆转录病毒与维斯纳病毒的遗传关系进行了研究。人类T细胞嗜淋巴细胞病毒包括与T细胞恶性肿瘤相关的病毒（HTLV-I和HTLV-II）和获得性免疫缺陷综合征的病原体（HTLV-III）。绵羊维斯纳病毒是慢病毒亚科的一个成员，是绵羊的一种慢复制、致病但不致癌的逆转录病毒。通过分子杂交和异源双链体分析获得的结果表明，HTVL-III和visna病毒之间的核苷酸序列同源性比HTLV-III和任何其他病毒之间存在更大的程度。在低严格性条件下观察到的同源性跨越整个基因组，但在gag/pol区域中最强。HTLV-III和visna病毒的形态发生和精细结构也表现出惊人的相似性。这些数据提供了强有力的证据HTLV-III和慢病毒亚科之间的密切的分类和进化关系。
A study was conducted of the genetic relation between human T-cell lymphotropic retroviruses and visna virus. The human T-cell lymphotropic viruses include those associated with T-cell malignancies (HTLV-I and HTLV-II) and the etiologic agent of the acquired immune deficiency syndrome (HTLV-III). Visna virus, a slowly replicating and pathogenic but nononcogenic retrovirus of sheep, is a member of the subfamily Lentivirinae. Results obtained by molecular hybridization and heteroduplex analysis indicated that a greater extent of nucleotide sequence homology exists between HTVL-III and visna virus than between HTLV-III and any of the other viruses. The homology observed under conditions of low stringency spanned the entire genome, but was strongest in the gag/pol region. The morphogenesis and fine structure of HTLV-III and visna virus also demonstrated striking similarities. The data provide strong evidence for a close taxonomic and evolutionary relation between HTLV-III and the Lentivirinae subfamily.