Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.
Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.
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通过一系列一锅式顺序方案模块化合成具有 α,β-不饱和化学型的新型大环化合物。
DOI：
10.1002/chem.201601004
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Hanson,PaulR
中科院分区：
文献类型：
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作者：
Javed,Salim;Bodugam,Mahipal;Torres,Jessica;Ganguly,Arghya;Hanson,PaulR
A series of one‐pot, sequential protocols was developed for the synthesis of novel macrocycles bearing α,β‐unsaturated chemotypes. The method highlights a phosphate tether‐mediated approach to establish asymmetry, and consecutive one‐pot, sequential processes to access the macrocycles with minimal purification procedures. This library amenable strategy provided diverse macrocycles containing α,β‐unsaturated carbon‐, sulfur‐, or phosphorus‐based warheads.
