Early olfactory processing in Drosophila: mechanisms and principles.

Early olfactory processing in Drosophila: mechanisms and principles.
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DOI:
10.1146/annurev-neuro-062111-150533
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发表时间:
2013-07-08
影响因子:
13.9
通讯作者:
Wilson RI
Wilson RI
中科院分区:
医学1区
文献类型:
--
作者:
Wilson RI

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In the olfactory system of Drosophila melanogaster, it is relatively straightforward to make in vivo measurements of activity in neurons corresponding to targeted processing. This, together with the numerical simplicity of the Drosophila olfactory system, has produced rapid gains in our understanding of Drosophila olfaction. This review summarizes the neurophysiology of the first two layers of this system: the peripheral olfactory receptor neurons and their postsynaptic targets in the antennal lobe. We now understand in some detail the cellular and synaptic mechanisms that shape odor representations in these neurons. Together, these mechanisms imply that interesting neural adaptations to environmental statistics have occurred and place some fundamental constraints on early sensory processing that pose challenges for higher brain regions. These findings suggest some general principles with broad relevance to early sensory processing in other modalities.
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