Genetic admixture, adipocytokines, and adiposity in black Americans: The health, aging, and body composition study
Genetic admixture, adipocytokines, and adiposity in black Americans: The health, aging, and body composition study
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DOI：
10.1007/s00439-007-0353-z
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发表时间：
2007-06-01
期刊：
影响因子：
5.3
通讯作者：
Ziv, Elad
中科院分区：
文献类型：
--
作者：
Fyr, Christina L. Wassel;Kanaya, Alka M.;Ziv, Elad
脂肪细胞因子是脂肪组织产生的细胞因子的一个子集，与II型糖尿病和动脉粥样硬化的风险有关。美国黑人和白人的脂肪细胞因子水平不同，即使在调整了肥胖症、与脂肪细胞因子相关的疾病(包括2型糖尿病和心血管疾病)以及一般社会经济状况指标(如收入)的差异后也是如此。在一项基于人群的美国黑人老年研究中，我们使用了一系列祖先信息标记来估计遗传祖先，并检查了遗传祖先与脂肪细胞因子和可溶性受体之间的联系，以帮助确定其中哪些可能最适合混合作图。我们在1,241名自报有可用DNA的美国黑人中键入了35个祖先信息标记，这些标记来自健康、老龄化和身体成分(Health ABC)研究中的可用DNA，并使用最大似然法估计欧洲血统的百分比。我们使用线性回归模型来确定这些脂肪细胞因子和祖先百分比之间的关联，并分阶段模型来检验肥胖或其他措施是否影响遗传祖先和脂肪细胞因子之间的关联。平均欧洲血统为22.3+/-15.9%。在多变量调整的模型中，观察到较高的欧洲血统与IL-6可溶性受体(IL-6 SR)、C反应蛋白(CRP)和脂联素水平之间的最强关联，而IL-2可溶性受体(IL-2 SR)和可溶性肿瘤坏死因子受体II(TNF-αSR II)也显示出较弱但显著的相关性。在调整了肥胖因素后，与脂联素的相关性变得更强。这些新的发现表明，混合作图可以识别影响IL-6SR、CRP、IL-2SR和脂联素水平的遗传因素。
Adipocytokines are a subset of cytokines produced by adipose tissue and are associated with risk of type II diabetes and atherosclerosis. Levels of adipocytokines differ between Black and White Americans, even after adjustment for differences in adiposity, diseases associated with adipocytokines including type 2 diabetes and cardiovascular disease, and general socioeconomic status indicators such as income. We used a series of ancestry informative markers to estimate genetic ancestry in a population-based study of older Black Americans, and examined the association between genetic ancestry and adipocytokines and soluble receptors to help determine which of these may be most amenable to admixture mapping. We typed 35 ancestry informative markers in 1,241 self-reported Black Americans with available DNA from the Health, Aging, and Body Composition (Health ABC) study with available DNA and used a maximum likelihood approach to estimate percent European ancestry. We used linear regression models to determine the association between these adipocytokines and percent ancestry, and staged models to examine whether adiposity or other measures affected the associations of genetic ancestry and adipocytokines. Mean European ancestry was 22.3 +/- 15.9%. In multivariate adjusted models, the strongest associations observed were between higher European ancestry and interleukin-6 soluble receptor (IL-6 SR), C-reactive protein (CRP), and adiponectin levels, with interleukin-2 soluble receptor (IL-2 SR) and soluble tumor necrosis factor receptor II (TNF-alpha SR II) also showing more modest but significant associations. The association with adiponectin became stronger after adjustment for adiposity. These novel findings suggest that admixture mapping may identify genetic factors influencing the levels of IL-6 SR, CRP, IL-2 SR, and adiponectin.