NIR Photothermal-Responsive Shape Memory Polyurethane with Protein-Inspired Aggregated Chymotrypsin-Sensitive Degradable Domains
NIR Photothermal-Responsive Shape Memory Polyurethane with Protein-Inspired Aggregated Chymotrypsin-Sensitive Degradable Domains
复制标题
具有蛋白质启发聚集的胰凝乳蛋白酶敏感可降解结构域的近红外光热响应形状记忆聚氨酯
DOI：
10.1002/marc.202200490
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发表时间：
2022
影响因子：
4.6
通讯作者：
Tan H
中科院分区：
文献类型：
--
作者：
Yang RB;Liu WK;Song NJ;Li X;Li Z;Luo F;Li JH;Tan H
可生物降解的形状记忆聚合物是一种很有前途的生物材料，用于微创外科手术，如肠支架。本文合成了一系列含有新型苯丙氨酸衍生扩链剂（PHP）的可生物降解形状记忆聚氨酯（smpu）。在高度进化的生物系统中，由于氨基酸的多重组合，蛋白质等生物大分子的功能丰富多样，本研究发现，PHP在SMPU中的序列分布也会对相结构和降解行为，特别是降解引起的表面形态差异产生很大的影响。考虑到制备的SMPU的转变温度（Ttrans）高于生理温度，将具有光热转换能力的氧化炭黑（OCB）引入SMPU中，不仅可以使SMPU具有近红外响应形状恢复特性，还可以提高SMPU的相分离度和力学性能。SMPU/OCB复合材料具有良好的形状记忆效应和快速的光热响应，可被胰凝乳蛋白酶降解，降解速率可调。这些SMPU/OCB复合材料作为肠道支架具有广泛的应用潜力。
Biodegradable shape memory polymers are promising biomaterials for stents used in minimally invasive surgical procedures such as intestinal stents. Herein, a series of biodegradable shape memory polyurethanes (SMPUs) containing a novel phenylalanine‐derived chain extender (PHP) are synthesized. Inspired by the fact that the function of biomacromolecules such as proteins is rich and varied because of the multiple combinations of the amino acid in highly evolved biosystems, this study finds that the sequence distribution of PHP in SMPU will also have a great influence on the phase structure and degradation behavior, especially the difference of surface morphology caused by degradation. Considering that the transition temperature (Ttrans) of SMPU obtained is higher than physiological temperature, oxidized carbon black (OCB) with the ability of photothermal conversion is introduced into SMPU, which can not only endow SMPU with near‐infrared response shape recovery characteristics, but also enhance phase separation degree and mechanical properties of them. SMPU/OCB composites show excellent shape memory effect and rapid photothermal response, and they can be degraded by chymotrypsin with an adjustable degradation rate. These SMPU/OCB composites show broad potential for application as intestinal stents.