The impact of TGF-beta on lung fibrosis: from targeting to biomarkers.
The impact of TGF-beta on lung fibrosis: from targeting to biomarkers.
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DOI：
10.1513/pats.201203-023aw
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发表时间：
2012-07-01
期刊：
影响因子：
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通讯作者：
Eickelberg, Oliver
中科院分区：
文献类型：
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作者：
Fernandez, Isis E;Eickelberg, Oliver
转化生长因子-β（TGF-β）广泛参与不同器官中纤维化的发展。其促纤维化作用的过度产生或增强导致纤维化过程开始期间的异常伤口愈合反应。特发性肺纤维化（IPF）是一种慢性、破坏性疾病，其中TGF-β 1诱导的稳态微环境的紊乱对于促进细胞活化、迁移、侵袭或增生性变化至关重要。此外，过量的细胞外基质产生在疾病发病机制中起主要作用。出于这个原因，本次审查将集中讨论新的数据，并强调在深化对TGF-β的促纤维化作用及其直接或间接靶向疾病调制的理解日益增长的兴趣。
Transforming growth factor-beta (TGF-beta) is extensively involved in the development of fibrosis in different organs. Overproduction or potentiation of its profibrotic effects leads to an aberrant wound healing response during the initiation of fibrotic processes. Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating disease, in which TGF-beta\x{2013}induced disturbances of the homeostatic microenvironment are critical to promote cell activation, migration, invasion, or hyperplastic changes. In addition, excess extracellular matrix production contributes in a major way to disease pathogenesis. For this reason, this review will focus on discussing novel data and highlight growing interest in deepening the understanding of the profibrotic role of TGF-beta and its direct or indirect targeting for disease modulation.