Quantitative Analysis of Lens Nuclear Density Using Optical Coherence Tomography (OCT) with a Liquid Optics Interface: Correlation between OCT Images and LOCS III Grading
Quantitative Analysis of Lens Nuclear Density Using Optical Coherence Tomography (OCT) with a Liquid Optics Interface: Correlation between OCT Images and LOCS III Grading
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DOI：
10.1155/2016/3025413
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发表时间：
2016-01-01
影响因子：
1.9
通讯作者：
Tchah, Hungwon
中科院分区：
文献类型：
--
作者：
Kim, You Na;Park, Jin Hyoung;Tchah, Hungwon
目的.使用具有液体光学接口的前节光学相干断层扫描（OCT）量化整个透镜和核透镜密度，并评价其与透镜混浊分类系统III（LOCS III）透镜分级和矫正远视力（BCVA）的相关性。方法.使用ImageJ软件分析年龄相关性核性白内障眼的整个透镜和透镜核的OCT图像。透镜等级和核密度以像素强度单位（PIU）表示，并评估PIU、BCVA和LOCS III之间的相关性。结果分析了47只眼睛。平均全透镜和透镜核密度分别为26.99 +/- 5.23和19.43 +/- 6.15 PIU。OCT图像和LOCS III获得的透镜混浊度（R-2 = 0.187，p < 0.01）和核密度（R-2 = 0.316，p < 0.01）之间存在正线性相关。术前BCVA和LOCS III也呈正相关（R-2 = 0.454，p < 0.01）。结论. OCT获得的全透镜和透镜核密度与LOCS III相关。核密度与LOCS III的相关性高于整个透镜密度。具有液体光学接口的OCT是一种潜在的透镜分级定量方法，可帮助监测和管理年龄相关性白内障。
Purpose. To quantify whole lens and nuclear lens densities using anterior-segment optical coherence tomography (OCT) with a liquid optics interface and evaluate their correlation with Lens Opacities Classification System III (LOCS III) lens grading and corrected distance visual acuity (BCVA). Methods. OCT images of the whole lens and lens nucleus of eyes with age-related nuclear cataract were analyzed using ImageJ software. The lens grade and nuclear density were represented in pixel intensity units (PIU) and correlations between PIU, BCVA, and LOCS III were assessed. Results. Forty-seven eyes were analyzed. The mean whole lens and lens nuclear densities were 26.99 +/- 5.23 and 19.43 +/- 6.15 PIU, respectively. A positive linear correlation was observed between lens opacities (R-2 = 0.187,p < 0.01) and nuclear density (R-2 = 0.316, p < 0.01) obtained from OCT images and LOCS III. Preoperative BCVA and LOCS III were also positively correlated (R-2 = 0.454, p < 0.01). Conclusions. Whole lens and lens nuclear densities obtained from OCT correlated with LOCS III. Nuclear density showed a higher positive correlation with LOCS III than whole lens density. OCT with a liquid optics interface is a potential quantitative method for lens grading and can aid in monitoring and managing age-related cataracts.