DETECTION OF STIMULUS DEVIANCE WITHIN PRIMATE PRIMARY AUDITORY-CORTEX - INTRACORTICAL MECHANISMS OF MISMATCH NEGATIVITY (MMN) GENERATION
DETECTION OF STIMULUS DEVIANCE WITHIN PRIMATE PRIMARY AUDITORY-CORTEX - INTRACORTICAL MECHANISMS OF MISMATCH NEGATIVITY (MMN) GENERATION
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DOI：
10.1016/0006-8993(94)91496-6
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发表时间：
1994-12-26
期刊：
影响因子：
2.9
通讯作者：
AREZZO, JC
中科院分区：
文献类型：
--
作者：
JAVITT, DC;STEINSCHNEIDER, M;AREZZO, JC
错配负波（MMN）是一种认知听觉事件相关电位（AEP），反映了刺激偏离的前注意检测，并指示听觉感觉（“回声”）记忆系统的操作。MMN最常在听觉古怪范式中引起，其中重复的标准刺激序列不频繁地且意外地被物理异常的“古怪”刺激中断。电和脑磁图偶极子映射的研究已经本地化的发电机MMN颞上听觉皮层附近的Heschl的回，但还没有确定的程度MMN反映激活初级听觉皮层（AI）本身。本研究，使用可移动的多通道电极急性插入到上级颞平面，证明了一个显着的贡献，AI头皮记录MMN的猴子，反映了更大的反应，AI大声或软点击作为偏差比相同的刺激作为重复的标准。MMN样活性主要定位于AI内的颗粒层上。因此，标准和偏差刺激引起类似程度的初始，丘脑皮层兴奋。与此相反，在颗粒上皮层的反应显着大于偏离刺激比标准。在穿透AI前部和内侧的有限数量的通过中未检测到MMN样活性。人工智能在解码个体刺激的声学特性方面发挥着重要作用。本研究表明，初级听觉皮层在处理刺激之间的关系中也起着重要的作用，因此参与了听觉信息的认知和纯粹的感觉加工。
Mismatch negativity (MMN) is a cognitive, auditory event-related potential (AEP) that reflects preattentive detection of stimulus deviance and indexes the operation of the auditory sensory ('echoic') memory system. MMN is elicited most commonly in an auditory oddball paradigm in which a sequence of repetitive standard stimuli is interrupted infrequently and unexpectedly by a physically deviant 'oddball' stimulus. Electro- and magnetoencephalographic dipole mapping studies have localized the generators of MMN to supratemporal auditory cortex in the vicinity of Heschl's gyrus, but have not determined the degree to which MMN reflects activation within primary auditory cortex (AI) itself. The present study, using moveable multichannel electrodes inserted acutely into superior temporal plane, demonstrates a significant contribution of AI to scalp-recorded MMN in the monkey, as reflected by greater response of AI to loud or soft clicks presented as deviants than to the same stimuli presented as repetitive standards. The MMN-like activity was localized primarily to supragranular laminae within AI. Thus, standard and deviant stimuli elicited similar degrees of initial, thalamocortical excitation. In contrast, responses within supragranular cortex were significantly larger to deviant stimuli than to standards. No MMN-like activity was detected in a limited number to passes that penetrated anterior and medial to AI. AI plays a well established role in the decoding of the acoustic properties of individual stimuli. The present study demonstrates that primary auditory cortex also plays an important role in processing the relationships between stimuli, and thus participates in cognitive, as well as purely sensory, processing of auditory information.