Long-term administration of mouse nerve growth factor to adult rats with partial lesions of the cholinergic septohippocampal pathway.
Long-term administration of mouse nerve growth factor to adult rats with partial lesions of the cholinergic septohippocampal pathway.
复制标题
对胆碱能隔海马通路部分损伤的成年大鼠长期施用小鼠神经生长因子。
DOI：
10.1016/0014-4886(90)90048-w
复制
发表时间：
1990
影响因子：
5.3
通讯作者：
Hefti,F
中科院分区：
文献类型：
--
作者：
Junard,EO;Montero,CN;Hefti,F
Nerve growth factor (NGF), a neurotrophic factor acting on cholinergic neurons of the basal forebrain, has been proposed as a treatment for Alzheimer's disease. Experimental support for its pharmacological use is derived from short-term studies showing that intraventricular administration of NGF during 2–4 weeks protects cholinergic cell bodies from lesion-induced degeneration, stimulates synthesis of choline acetyltransferase, and improves various behavioral impairments. To investigate the consequences of long-term NGF administration, we tested whether cholinergic cell bodies are protected from lesion-induced degeneration and whether cholinergic axons are stimulated to regrow into the denervated hippocampus following fimbrial transections. We found that intraventricular injections of NGF twice a week for 5 months to adult rats resulted in extended protection of cholinergic cell bodies from lesion-induced degeneration and did not produce obvious detrimental effects on the animals. NGF treatment mildly stimulated growth of cholinergic neurites within the 2-mm area directly adjacent to the fimbrial lesion but it failed to induce significant homotypic growth of cholinergic neurites into the deafferented hippocampus.
