Functional columns in the primate prefrontal cortex revealed by optical imaging in vitro
Functional columns in the primate prefrontal cortex revealed by optical imaging in vitro
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DOI：
10.1016/j.neures.2008.01.003
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发表时间：
2008-05-01
影响因子：
2.9
通讯作者：
Sawaguchi, Toshiyuki
中科院分区：
文献类型：
--
作者：
Hirata, Yoshihiro;Sawaguchi, Toshiyuki
虽然灵长类动物的背外侧前额叶皮层（DLPFC）中存在功能柱，但它的动态甚至存在性仍然不确定。我们进行了光学记录与电压敏感染料（RH 482）在脑切片从主沟区域（46区）的猕猴。电刺激中层（下层III或IV层）会诱发柱状活动;该活动由两个部分组成：可能是动作电位和兴奋性突触后电位。当刺激的电流强度超过一定水平时，即在具有该强度的峰值处约900 μ m时，柱状活性的宽度饱和。同一切片内不同部位的刺激激活了不同的柱状活动，只有轻微的重叠。此外，类似的柱状活动出现时，不同的网站与柱状活动的区域内受到刺激。这些发现表明，灵长类动物的DLPFC由兴奋性突触连接形成的功能柱组成。(c)2008年爱思唯尔爱尔兰有限公司和日本神经科学学会。All rights reserved.
Although the functional column has been implicated in the dorsolateral prefrontal cortex (DLPFC) of primates, its dynamics and even existence are still uncertain. We performed optical recording with a voltage-sensitive dye (RH482) in brain slices obtained from the principal sulcal region (area 46) of macaque monkeys. Columnar activity was evoked by electrical stimulation of the middle layer (lower layer III or layer IV); this activity consisted of two components: probably action potentials and excitatory postsynaptic potentials. The width of the columnar activity was saturated when the current intensity of stimulation exceeded a certain level, that is, approximately 900 mu m at the peak with this intensity. The stimulation of different sites within the same slice activated different columnar activities with only slight overlaps. Furthermore, similar columnar activity appeared when a different site within the area with columnar activity was stimulated. These findings suggest that the primate DLPFC consists of functional columns formed by excitatory synaptic connections., (c) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.