Fine‐needle aspiration cytology and core biopsy of malignant peripheral nerve sheath tumor of the uterus: A case report
Fine‐needle aspiration cytology and core biopsy of malignant peripheral nerve sheath tumor of the uterus: A case report
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子宫恶性周围神经鞘瘤的细针穿刺细胞学检查和核心活检：一例报告
DOI：
10.1002/dc.1075
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发表时间：
2001
影响因子：
1.3
通讯作者：
R. Logroño
中科院分区：
文献类型：
--
作者：
C. P. Molina;B. Burton Putegnat;R. Logroño
恶性周围神经鞘瘤是一种罕见的神经源性间叶肿瘤。发生在子宫内的MPNST是非常罕见的。其组织学表现在这一解剖位置已很少报告。一名62岁女性，既往有部分子宫切除术史，子宫残端有一个大的盆腔肿块。在超声引导下进行细针穿刺（FNA）和芯活检，并确定MPNST的诊断。细胞学和组织学结果与提示MPNST的梭形细胞肿瘤一致。肿瘤细胞对S-100蛋白免疫染色呈局灶性阳性，从而进一步支持肿瘤的神经鞘分化。患者无von Recklinghausen病史。肿块切除证实了MPNST的诊断。据我们所知，在这个不寻常的位置MPNST的FNA细胞学以前没有报道。细针穿刺细胞学检查，沿着空芯针吸活检和免疫组化，是诊断MPNST的可靠工具。细胞病理学诊断。24：347-351，2001.© 2001 Wiley利斯公司
Malignant peripheral nerve sheath tumor (MPNST) is an uncommon mesenchymal neoplasm of neural origin. MPNST arising in the uterus is extremely rare. Its histologic appearance on this anatomical location has been only rarely reported. A 62‐yr‐old woman with a previous history of partial hysterectomy presented with a large pelvic mass in the uterine stump. Fine‐needle aspiration (FNA) and core biopsy were obtained under ultrasonographic guidance, and the diagnosis of MPNST was established. The cytologic and histologic findings were consistent with a spindle‐cell neoplasm suggestive of MPNST. The tumor cells were focally positive for S‐100 protein immunostain, thus providing further support for the neoplasm's nerve sheath differentiation. The patient had no history of von Recklinghausen's disease. Resection of the mass confirmed the diagnosis of MPNST. To our knowledge, the FNA cytology of MPNST in this unusual location has not been previously reported. FNA cytology, along with core biopsy and immunochemistry, is a reliable tool in the diagnosis of MPNST. Diagn. Cytopathol. 24:347–351, 2001. © 2001 Wiley‐Liss, Inc.