Individual Variation in Paternal Responses of Virgin Male California Mice (Peromyscus californicus): Behavioral and Physiological Correlates
Individual Variation in Paternal Responses of Virgin Male California Mice (Peromyscus californicus): Behavioral and Physiological Correlates
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DOI：
10.1086/665831
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发表时间：
2012-11-01
影响因子：
1.6
通讯作者：
Saltzman, Wendy
中科院分区：
文献类型：
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作者：
de Jong, Trynke R.;Korosi, Aniko;Saltzman, Wendy
加州鼠Peromyscus californicus是一种啮齿类动物，其中父亲提供广泛的父系照顾;然而，未交配雄性对同种新生儿的行为反应从父系行为到对杀鼠剂的耐受性各不相同。间接证据表明，父亲的反应可能会受到社会地位的影响，可能通过增加压力和焦虑的下属男性。为了验证这一假设，我们将12只雄性加州处女小鼠置于断奶时的同性配对中，并使用食物竞争和尿液标记试验评估其配对内的从属或主导地位。此外，行为反应无关的小狗，加压素（AVP）和促肾上腺皮质激素释放激素（CRH）的室旁核（PVN）的mRNA的表达，基础血浆睾酮和皮质酮水平，体重进行了测量。食物竞争和尿液标记测试没有显示出强烈或稳定的显性从属关系，在男性-男性二对。嗅新生幼犬的潜伏期与新环境中心的尿液标记呈负相关，与PVN中AVP mRNA的表达呈正相关。由于这三个参数都与其他啮齿类动物的状态焦虑，这些结果表明，父亲的反应的个体差异可能会受到焦虑的个体差异，但不一定是由社会地位的处女雄性加州小鼠。
California mice Peromyscus californicus are a rodent species in which fathers provide extensive paternal care; however, behavioral responses of virgin males toward conspecific neonates vary from paternal behavior to tolerance to infanticide. Indirect evidence suggests that paternal responses might be influenced by social status potentially through increased stress and anxiety in subordinate males. To test this hypothesis, we housed 12 virgin male California mice in same-sex dyads on weaning and assessed their within-dyad subordinate or dominant status using food-competition and urine-marking tests. In addition, behavioral responses to an unrelated pup, expression of vasopressin (AVP) and corticotropin-releasing hormone (CRH) mRNA in the paraventricular hypothalamic nucleus (PVN), basal plasma levels of testosterone and corticosterone, and body mass were measured. Food-competition and urine-marking tests did not reveal strong or stable dominance-subordination relationships in male-male dyads. Latency to sniff a newborn pup was correlated negatively with urine marking in the center of a novel environment and positively with expression of AVP mRNA in the PVN. Because these three parameters are all associated with state anxiety in other rodent species, these results suggest that individual differences in paternal responsiveness may be influenced by individual differences in anxiety but not necessarily by social status in virgin male California mice.