Dragon's Blood extract has antithrombotic properties, affecting platelet aggregation functions and anticoagulation activities
Dragon's Blood extract has antithrombotic properties, affecting platelet aggregation functions and anticoagulation activities
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DOI：
10.1016/j.jep.2011.03.063
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发表时间：
2011-05-17
影响因子：
5.4
通讯作者：
Deng, Yu-Lin
中科院分区：
文献类型：
--
作者：
Xin, Nian;Li, Yu-Juan;Deng, Yu-Lin
民族药理学相关性：龙血从龙血树（Lour.）陈参（S.C. Chen，中国云南）作为一种传统中草药，具有一定的抗血栓作用。研究了从龙血中提取有效成分的新工艺。得到95%乙醇提取物A （EA）和沉淀物B (PB)，并进行了比较。通过药效学实验验证了制备工艺的可靠性。材料与方法：建立大鼠/小鼠血栓形成和血瘀模型，分析EA和PB对血栓形成、血小板功能和凝血活性的影响。结果：EA部位对血栓形成的抑制作用（p < 0.05）、血小板聚集功能（p < 0.01）和抗凝血活性（p < 0.05 ~ 0.01）均显著优于PB部位。结论：龙血EA部分含有抗血栓作用的有效药理成分，部分改善血小板功能和抗凝血活性。2011爱思唯尔爱尔兰有限公司版权所有。
Ethnopharmacological relevance: Dragon's Blood from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China), as a traditional Chinese medicinal herb, was shown to have certain antithrombotic effects. A new preparation process was used to extract effective components from Dragon's Blood. A 95% ethanol extract A (EA) and a precipitate B (PB) fraction were obtained and compared. Reliability of the preparation process was validated by pharmacodynamic experiments.Materials and methods: A rat/mouse thrombosis and blood stasis model was developed for this study, and EA and PB effects on thrombosis, platelet functions and blood coagulation activities were analyzed.Results: It was observed that the EA fraction had significantly better inhibitory effects than the PB fraction on thrombosis (p < 0.05), platelet aggregation function (p < 0.01) and anticoagulation activity (p < 0.05-0.01).Conclusions: The results obtained here showed that EA fraction from Dragon's Blood contained pharmacologically effective compounds with antithrombotic effects, partially improving platelet function and anticoagulation activity. (C) 2011 Elsevier Ireland Ltd. All rights reserved.