Chemerin Level and the Relation to Insulin Resistance in Chronic Kidney Disease
Chemerin Level and the Relation to Insulin Resistance in Chronic Kidney Disease
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DOI：
10.4103/1319-2442.275482
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发表时间：
2019-11-01
影响因子：
0.5
通讯作者：
Hamed, Soha Talat
中科院分区：
文献类型：
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作者：
El-Khashab, Sahier Omar;Gamil, Mona;Hamed, Soha Talat
Chemerin与代谢综合征的不同组分相关，包括高血压、高脂血症和胰岛素抵抗（IR）。本研究的目的是评估慢性肾脏病（CKD）患者的血清chemerin水平及其与IR的关系。本研究对80名参与者进行，他们被分为三组：组I（30例CKD患者，平均年龄53 ± 12岁），第二组（30例接受定期血液透析的终末期肾病患者，平均年龄48 ± 14.8岁），第三组有20例年龄和性别匹配的健康对照。测定血清chemerin水平、空腹血糖、空腹胰岛素、HOMA-IR指数计算、尿素、肌酐、估计肾小球滤过率、总胆固醇和甘油三酯。采用双能X线吸收测定法评估身体成分。在I组和II组中，我们发现与健康对照组相比，平均chemerin水平显著更高（P
Chemerin has been associated with different components of the metabolic syndrome, including hypertension, hyperlipidemia, and insulin resistance (IR). The aim of this study was to evaluate serum chemerin level in chronic kidney disease (CKD) patients and its relation to IR. This study was conducted on 80 participants who were classified into three groups: Group I (30 CKD patients with mean age 53 +/- 12 years), Group II (30 patients with end-stage renal disease on regular hemodialysis with mean age 48 +/- 14.8 years) and Group III having 20 healthy age- and sex-matched controls. Serum chemerin level, fasting blood sugar, fasting insulin, HOMA-IR index calculation, urea, creatinine, estimated glomerular filtration rate, total cholesterol, and triglyceride were measured. Body composition was assessed by dual-energy Xray absorptiometry. In Groups I and II, we found a significantly higher mean chemerin level compared to healthy controls (P