REPEATED ADMINISTRATION OF TRIIODOTHYRONINE ENHANCES THE SUSCEPTIBILITY OF RATS TO ISONIAZID-INDUCED AND PICROTOXIN-INDUCED SEIZURES
REPEATED ADMINISTRATION OF TRIIODOTHYRONINE ENHANCES THE SUSCEPTIBILITY OF RATS TO ISONIAZID-INDUCED AND PICROTOXIN-INDUCED SEIZURES
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DOI：
10.1016/0024-3205(92)90486-9
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发表时间：
1992-01-01
期刊：
影响因子：
6.1
通讯作者：
BERTOLINI, A
中科院分区：
文献类型：
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作者：
SANDRINI, M;MARRAMA, D;BERTOLINI, A
在甲状腺机能亢进的实验条件下，通过在成年大鼠中重复施用三碘甲腺原氨酸（100 μ g/kg/天，连续7天皮下注射）获得，对异烟肼（300 mg/kg，ip）和印防己毒素（4 mg/kg，ip）的惊厥作用的敏感性增加。另一方面，脑[H-3]氟硝西泮结合位点的特征未改变。这些数据为甲状腺激素对脑功能的影响提供了进一步的实验证据。
In an experimental condition of hyperthyroidism, obtained by repeated administration of triiodothyronine in adult rats (100-mu-g/kg/day, sc for 7 consecutive days), there is an increased susceptibility to the convulsant effect of isoniazid (300 mg/kg, ip) and picrotoxin (4 mg/kg, ip). On the other hand, the characteristics of brain [H-3] flunitrazepam binding sites are not modified. These data afford further experimental evidence of the influence of thyroid hormones on brain function.