Transmission of human papillomavirus in heterosexual couples.
Transmission of human papillomavirus in heterosexual couples.
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DOI：
10.3201/eid1406.070616
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发表时间：
2008-06
影响因子：
11.8
通讯作者：
Goodman MT
中科院分区：
文献类型：
--
作者：
Hernandez BY;Wilkens LR;Zhu X;Thompson P;McDuffie K;Shvetsov YB;Kamemoto LE;Killeen J;Ning L;Goodman MT
从阴茎到子宫颈的传播率低于从子宫颈到阴茎的传播率； 13种不同的基因型是通过性传播的。我们检查了 25 对异性一夫一妻制夫妇（25 名男性，25 名女性）中人乳头瘤病毒 (HPV) 的传播情况，并进行了平均 7.5 个月的随访。在 16 对夫妇中总共观察到 53 起异性传播事件（14 起男传女，39 起女传男）。性传播涉及 13 种不同的致癌和非致癌 HPV 类型； 8% 是在伴侣之间传播的疫苗覆盖类型。 HPV从阴茎到宫颈的总体传播率为4.9/100人月，远低于从宫颈到阴茎的HPV传播率（17.4/100人月）。还观察到手和生殖器之间的传播以及明显的自我接种事件（主要在男性中）。传播 HPV 的夫妇性行为更加活跃，并且使用安全套的频率也较低。这些结果对 HPV 预防和控制策略具有影响，包括预防性疫苗的针对性。
Rate of transmission from penis to cervix was lower than that from cervix to penis; 13 different genotypes were sexually transmitted. We examined the transmission of human papillomavirus (HPV) in 25 heterosexual, monogamous couples (25 men, 25 women), followed up over an average of 7.5 months. A total of 53 heterosexual transmission events were observed among 16 couples (14 male-to-female and 39 female-to-male). Sexual transmission involved 13 different oncogenic and nononcogenic HPV types; 8% were vaccine-covered types transmitted between partners. The overall rate of HPV transmission from the penis to the cervix was 4.9/100 person-months, which was substantially lower than that from the cervix to the penis (17.4/100 person-months). Transmission between the hands and genitals, as well as apparent self-inoculation events (primarily in men), were also observed. Couples who transmitted HPV were more sexually active and used condoms less frequently. These results have implications for HPV prevention and control strategies, including the targeting of prophylactic vaccines.