Modulation of dorsal thalamic cell activity by the ventral pallidum: its role in the regulation of thalamocortical activity by the basal ganglia.
Modulation of dorsal thalamic cell activity by the ventral pallidum: its role in the regulation of thalamocortical activity by the basal ganglia.
复制标题
腹侧苍白球对背侧丘脑细胞活动的调节：其在基底神经节调节丘脑皮质活动中的作用。
DOI：
10.1002/syn.890180205
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Grace,AA
中科院分区：
文献类型：
--
作者：
Lavin,A;Grace,AA
用细胞内记录的方法研究了刺激苍白球腹侧核(VP)对丘脑多个靶核(包括丘脑背核和网状核)神经元活动的影响，以探讨基底神经节边缘系统输出投射的作用。在实验的一个子集中，使用了荧光黄的细胞内注射来识别记录的神经元，并确认它们相对于特定的丘脑核团的位置。刺激VP可在79%的背内侧细胞中诱发IPSP。在网状核，73%的受试神经元对诱发的IPSP有反应。相反，在其他丘脑背侧核团中，刺激VP引起58%的细胞去极化。背内侧核和网状核IPSP的起始潜伏期无显著差异(1.7±1.1毫秒对2.7±1.1毫秒)，而丘脑背侧核神经元诱发的去极化反应潜伏期较长且变化较大(3.5±2.7毫秒)。
The actions mediated by limbic system output projections of the basal ganglia were investigated by studying the effects of ventral pallidum (VP) stimulation on the activity of neurons in thalamic target nuclei, including several of the dorsal thalamic nuclei and the nucleus reticularis, using in vivo intracellular recordings in rats. Intracellular injection of Lucifer yellow was used in a subset of experiments to identify the neurons recorded and to confirm their location with respect to the specific thalamic nuclei targeted. Stimulation of the VP evoked ipsps in 79% of the mediodorsal cells recorded. In the reticular nucleus, 73% of the neurons tested responded with evoked ipsps. In contrast, in other dorsal thalamic nuclei VP stimulation evoked depolarizations in 58% of the cells recorded. The latency to onset of the ipsps in the mediodorsal nucleus and in the reticular nucleus were not substantially different (1.7 ± 1.1 msec vs. 2.7 ± 1.1 msec), whereas the depolarizing response evoked in dorsal thalamic nucleus neurons typically occurred at longer and more variable latencies (3.5 ± 2.7 msec).