ASSOCIATION OF SERUM ANTI-THYROID ANTIBODIES WITH LYMPHOCYTIC INFILTRATION OF THYROID-GLAND - STUDIES OF 70 AUTOPSIED CASES
ASSOCIATION OF SERUM ANTI-THYROID ANTIBODIES WITH LYMPHOCYTIC INFILTRATION OF THYROID-GLAND - STUDIES OF 70 AUTOPSIED CASES
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DOI：
10.1210/jcem-46-6-859
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发表时间：
1978-01-01
影响因子：
5.8
通讯作者：
KUMAHARA, Y
中科院分区：
文献类型：
--
作者：
YOSHIDA, H;AMINO, N;KUMAHARA, Y
对70例无明显甲状腺疾病的患者进行了甲状腺组织学检查和血清抗甲状腺抗体测定。淋巴细胞浸润12例，抗甲状腺球蛋白血凝抗体（TGHA）2例，抗甲状腺微粒体血凝抗体（MCHA）9例。女性淋巴细胞浸润的发生率是男性的3倍。12例有淋巴细胞浸润者中10例抗体阳性（TGHA或MCHA），11例抗体阳性者中10例有淋巴细胞浸润。形态学和血清学检查结果之间的相关性非常显著，P < 0.001。淋巴细胞浸润和/或抗体阳性患者甲状腺重量小于15 g的小甲状腺发生率高于甲状腺正常患者。无明显甲状腺疾病的受试者血清抗甲状腺抗体阳性可能表明甲状腺存在淋巴细胞浸润，推测为亚临床自身免疫性甲状腺炎。
Postmortem histological examination of the thyroid gland and measurement of serum antithyroid antibodies were performed in 70 patients without overt thyroid disease. Lymphocytic infiltration, antithyroglobulin hemagglutination antibody (TGHA) and antithyroid microsomal hemagglutination antibody (MCHA) were found in 12, 2 and 9 cases, respectively. The incidence of lymphocytic infiltration in females was 3 times that in males. Ten of the 12 cases with lymphocytic infiltration had positive antibodies (TGHA or MCHA), while 10 of 11 patients with positive antibodies showed lymphocytic infiltration. The correlation between morphological and serological findings was highly significant at P < 0.001. The incidence of a small thyroid gland of less than 15 g in weight was higher in patients with lymphocytic infiltration and/or positive antibodies than in patients with a normal thyroid gland. Positive serum antithyroid antibodies in subjects without overt thyroid disease may indicate the existence of lymphocytic infiltration in the thyroid gland, that is presumably subclinical autoimmune thyroiditis.