Dynamical systems theory of cellular reprogramming
Dynamical systems theory of cellular reprogramming
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DOI：
10.1103/physrevresearch.4.l022008
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发表时间：
2021-09
影响因子：
4.2
通讯作者：
Yuuki Matsushita;Tetsuhiro S. Hatakeyama;K. Kaneko
中科院分区：
文献类型：
--
作者：
Yuuki Matsushita;Tetsuhiro S. Hatakeyama;K. Kaneko
在细胞重编程中，几乎所有分化细胞的表观遗传记忆都被少数基因的过表达所消除，重新获得多能性，即分化的潜力。考虑到振荡基因表达和较慢的表观遗传修饰之间的相互作用，这种重编程被认为是对鞍形不稳定流形的不直观的全局吸引，鞍形不稳定流形代表了多能性。该方案的普遍性得到了阻遏子模型、随机生成的基因调控网络和从胚胎干细胞中提取的基因调控网络的证实。
In cellular reprogramming, almost all epigenetic memories of differentiated cells are erased by the overexpression of few genes, regaining pluripotency, potentiality for differentiation. Considering the interplay between oscillatory gene expression and slower epigenetic modifications, such reprogramming is perceived as an unintuitive, global attraction to the unstable manifold of a saddle, which represents pluripotency. The universality of this scheme is confirmed by the repressilator model, and by gene regulatory networks randomly generated and those extracted from embryonic stem cells.