Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016
Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016
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DOI：
10.1007/s12250-017-4077-5
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发表时间：
2017-12-01
影响因子：
5.5
通讯作者：
Deng, Fei
中科院分区：
文献类型：
--
作者：
Shi, Junming;Su, Zhengyuan;Deng, Fei
基孔肯雅病毒（Chikungunya virus，CHIKV）是一种蚊媒病毒，在世界上特别是在热带和亚热带地区引起广泛流行。系统发育分析发现，CHIKV的谱系与空间和时间分布相关，这与病毒对主要蚊种的适应性及其分布有关。在这项研究中，我们报告了去年在巴基斯坦爆发的8株CHIKV分离株的全基因组序列。然后，我们使用广泛的系统发育分析回顾了CHIKV的进化历史，分析了病毒蛋白的谱系特异性取代，并表征了包括巴基斯坦毒株在内的CHIKV毒株的传播途径。结果表明，巴基斯坦菌株属于ECSA.IOL亚系，来源于印度。进一步表征了巴基斯坦毒株的遗传特性，包括对载体的适应性替换，并讨论了巴基斯坦发生CHIKV感染的潜在风险。这些结果有助于更好地了解CHIKV在全球的演变和传播，并揭示了巴基斯坦CHIKV爆发和流行的可能起源，这将促进已确定的有CHIKV感染史的国家和地区以及具有CHIKV爆发潜在风险的新地区的疾病预防和控制。
Chikungunya virus (CHIKV) is a mosquito-borne virus that causes epidemics widely in the world especially in the tropical and subtropical regions. Phylogenetic analysis has found that the CHIKV lineages were associated with the spatial and temporal distributions, which were related to the virus adaption to the major mosquito species and their distributions. In this study, we reported the complete genome sequences of eight CHIKV isolates from the outbreak in Pakistan last year. Then we reviewed the evolutionary history using extensive phylogenetic analysis, analyzed lineage-specific substitutions in viral proteins, and characterized the spreading pathway of CHIKV strains including the Pakistani strains. The results showed that the Pakistani stains belonged to the ECSA.IOL sub-lineage and derived from India. The genetic properties of the Pakistani strains including the adaptive substitution to vectors were further characterized, and the potential risks from the occurrence of CHIKV infection in Pakistan were discussed. These results provided better understanding of CHIKV evolution and transmission in the world and revealed the possible origination of the CHIKV outbreak and epidemic in Pakistan, which would promote the disease prevention and control in the identified countries and territories with the history of CHIKV infections as well as new regions with potential risk of CHIKV outbreaks.