Altered cingulate white. matter connectivity in panic disorder patients
Altered cingulate white. matter connectivity in panic disorder patients
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DOI：
10.1016/j.jpsychires.2007.03.002
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发表时间：
2008-04-01
影响因子：
4.8
通讯作者：
Lyoo, In Kyoon
中科院分区：
文献类型：
--
作者：
Han, Doug Hyun;Renshaw, Perry F.;Lyoo, In Kyoon
目的：对惊恐障碍受试者的功能成像研究表明，大脑扣带回区域的激活增加。本研究旨在探讨惊恐障碍患者与健康对照组脑白质连通性的差异。方法：对24例惊恐障碍患者和24例年龄、性别匹配的健康对照组的前扣带回和后扣带回的结构白质连通性进行了检测。结果：惊恐障碍患者左侧扣带前区和右侧后扣带区的FA值明显高于对照组(分别为13.3%和19.6%)。根据惊恐障碍严重程度评分，这两个扣带区的白质连接性也与临床严重程度呈正相关。左侧前扣带回FA值与追踪时间呈负相关，与数字符号替代试验呈正相关。结论：惊恐障碍患者左侧前扣带回和右侧后扣带回脑白质连通性存在潜在的“增强”，这些变化可能在惊恐障碍的临床症状中起重要作用。(C)2007爱思唯尔有限公司。保留所有权利。
Objcctive: Functional imaging studies of panic disorder subjects suggest an increased activation of the cingulate regions of the brain. Aim of the current study was to explore the white matter connectivity differences between subjects with panic disorder and healthy comparison subjects.Method: Structural white matter connectivity, as determined front fractional anisotropy (FA) values obtained by diffusion tensor imaging, was assessed for anterior and posterior cingulate regions in 24 panic disorder patients and 24 age and sex-matched healthy comparison subjects.Results: Subjects with panic disorder exhibited significantly greater FA values in left anterior and right posterior cingulate regions (by 13.3% and 19.6%, respectively) relative to comparison subjects. White matter connectivity for these two cingulate regions was also positively correlated with clinical severity, as determined by Panic Disorder Severity Scale. FA values in left anterior cingulate region negatively correlated with the time of Trail Making Tests and positively with Digit Symbol Substitution Test.Conclusions: Findings suggest a potential 'enhancement' in white matter connectivity in left anterior and right posterior cingulate regions in panic disorder, and that these changes may play an important role in mediating clinical symptoms of panic disorder. (C) 2007 Elsevier Ltd. All rights reserved.