Executive cognitive deficits in primary dystonia
Executive cognitive deficits in primary dystonia
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DOI：
10.1002/mds.10399
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发表时间：
2003-05-01
影响因子：
8.6
通讯作者：
Aziz, T
中科院分区：
文献类型：
--
作者：
Scott, RB;Gregory, R;Aziz, T
原发性肌张力障碍是一种运动障碍，尚未确定一致的病理生理学;在缺乏相反证据的情况下，假定其为认知良性。我们研究了一组临床异质性的14例原发性肌张力障碍的神经心理测试电池。尽管与正常对照组相比，信息处理、语言、空间、记忆和一般智力技能的速度保持良好，但我们在剑桥神经心理测试自动化组合（CANTAB）上发现了一系列注意力-执行认知缺陷。具体来说，患者表现出显着的困难谈判额外的维度设置移位阶段的IED任务。这些研究结果的病理生理原发性肌张力障碍的影响进行了讨论。据我们所知，这是首次报道原发性肌张力障碍患者存在显著的认知缺陷。(C)2003年，为社会运动员。
Primary dystonia is a disorder of movement for which no consistent pathophysiology has been identified; in the absence of evidence to the contrary, it is assumed to be cognitively benign. We have studied a clinically heterogeneous group of 14 patients with primary dystonia on a battery of neuropsychological tests. Despite well-preserved speed of information processing, language, spatial, memory and general intellectual skills relative to normal controls, we have identified a constellation of attentional-executive cognitive deficits on the Cambridge Neuropsychological Test Automated Battery (CANTAB). Specifically, patients demonstrated significant difficulties negotiating the extra-dimensional set-shifting phase of the IED task. The implications of these findings for the pathophysiology of primary dystonia are discussed. This is, to the best of our knowledge, the first report of a significant cognitive deficit in patients with primary dystonia. (C) 2003 Movement Disorder Society.