VISUOSPATIAL CODING IN PRIMATE PREFRONTAL NEURONS REVEALED BY OCULOMOTOR PARADIGMS
VISUOSPATIAL CODING IN PRIMATE PREFRONTAL NEURONS REVEALED BY OCULOMOTOR PARADIGMS
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DOI：
10.1152/jn.1990.63.4.814
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发表时间：
1990-04-01
影响因子：
2.5
通讯作者：
GOLDMANRAKIC, PS
中科院分区：
文献类型：
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作者：
FUNAHASHI, S;BRUCE, CJ;GOLDMANRAKIC, PS
1.通过记录恒河猴在完成视觉延迟反应（ODR）和视觉探测（VP）任务时前额叶皮层单个神经元的活动，研究了视觉反应及其与延迟期活动的关系。在ODR任务中，要求猴子在整个提示（0.5 s）和延迟（3 s）期间保持对中心光点的固定，然后对呈现视觉提示的四个或八个位置之一进行扫视眼球运动。在VP任务中，ODR任务中使用的相同视觉刺激被呈现0.5秒，但不需要反应。因此，VP任务被用来测试被动视觉反应，并通过与ODR任务中的线索引发的活动进行比较，以检查前额视觉活动中存在的行为增强的程度。2.在434个神经元记录从前额叶皮层内和周围的主沟（PS），261任务相关的活动在至少一个阶段的ODR任务，和74这些有阶段性的视觉反应的发病的视觉线索的中位潜伏期为116 ms。69个神经元的视觉反应是兴奋性的，和5个神经元被抑制。五个神经元的兴奋性视觉反应也作出了短暂的反应后，偏移的线索。3.视觉反应被归类为方向性的71 PS神经元（96%）的兴奋性或抑制性反应只发生在有限的部分视野的线索的位置。只有3个PS神经元是全向的，在所有测试地点对线索的反应都是一样的。4.所有PS神经元的定向视觉反应的最佳方向和调谐特异性估计从参数产生最佳拟合高斯形调谐函数。大多数神经元（71%）的最佳方向是朝向神经元所在半球对侧的视野。其余神经元的最佳方向在同侧野（18%）或沿着垂直经线（11%）。5. PS视觉反应的定向调谐的特异性是相当可变的，范围从只对八个线索位置之一作出反应的神经元到对所有八个作出反应的神经元，但以明确分级的方式。高斯曲线的标准差参数表示每个神经元定向调谐的宽度，其中值为37度。（400字处删节）
1. Visual responses and their relationship to delay-period activity were studied by recording single neuron activity from the prefrontal cortex of rhesus monkeys while they performed an oculomotor delayed-response (ODR) and a visual probe (VP) task. In the ODR task, the monkey was required to maintain fixation of a central spot of light throughout the cue (0.5 s) and delay (3 s) periods and then make a saccadic eye movement to one of four or eight locations where the visual cue had been presented. In the VP task, the same visual stimuli that were used in the ODR task were presented for 0.5 s, but no response was required. The VP task was thus employed to test the passive visual response and, by comparison with cue-elicited activity in the ODR task, to examine the degree of behavioral enhancement present in prefrontal visual activity. 2. Among 434 neurons recorded from the prefrontal cortex within and surrounding the principal sulcus (PS), 261 had task-related activity during at least one phase of the ODR task, and 74 of these had phasic visual responses to the onset of the visual cues with a median latency of 116 ms. The visual responses of 69 neurons were excitatory, and 5 neurons were inhibited. Five of the neurons with excitatory visual responses also responded transiently after the offset of the cue. 3. Visual responses were classified as directional for 71 PS neurons (96%) in that excitatory or inhibitory responses occurred only for location of cues in a restricted portion of the visual field. Only 3 PS neurons were omnidirectional, i.e., responded equivalently to cues in all locations tested. 4. The best direction and tuning specificity of all PS neurons with directional visual responses were estimated from parameters yielding the best fit to a Gaussian-shaped tuning function. The best direction for the majority (71%) of neurons was toward the visual field contralateral to the hemisphere where the neuron was located. The remaining neurons had their best directions in the ipsilateral field (18%) or along the vertical meridian (11%). 5. The specificity of directional tuning for PS visual responses was quite variable, ranging from neurons that responded only to one of the eight cue locations to neurons that responded to all eight, but in a clearly graded fashion. The standard deviation parameter of the Gaussian curve indexed the breadth of directional tuning of each neuron; its median value was 37 degrees.(ABSTRACT TRUNCATED AT 400 WORDS)