Which FDG/PET parameters of the primary tumors in colon or sigmoid cancer provide the best correlation with the pathological findings?
Which FDG/PET parameters of the primary tumors in colon or sigmoid cancer provide the best correlation with the pathological findings?
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DOI：
10.1016/j.ejrad.2013.04.022
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发表时间：
2013-09-01
影响因子：
3.3
通讯作者：
Kao, Chia-Hung
中科院分区：
文献类型：
--
作者：
Chen, Shang-Wen;Chen, William Tzu-Liang;Kao, Chia-Hung
目的比较原发性结肠癌和乙状结肠癌（CSC）的18氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）相关参数与病理结果的关系。使用几种自动分割方法确定基于PET的最大肿瘤长度（TL）和肿瘤宽度（TW），并测量代谢肿瘤体积（MTV）和总病变糖酵解（TLG）的各种阈值。结果使用30%阈值水平的TL（TL 30%）和TW（TW 30%）的最大摄取产生的结果提供了与最大病理长度（R = 0.81，p < 0.001）和宽度（R = 0.70，p < 0.001）的最佳匹配。TW30%是预测病理T3或T4分期的独立因素（OR = 1.26，95% CI = 1.07-1.47，p = 0.01）。受试者工作特征曲线显示，MTV在40%最大摄取（MTV 40%）的固定阈值下，TW 30%与晚期病理T分期具有较好的相关性。结论治疗前PET/CT是预测CSC患者最终病理结果的有用工具。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Background To compare F-18-fluoro-2-deoxdeoxyglucose (FDG) positron emission tomography (PET) related parameters of primary colon or sigmoid cancer (CSC) with pathological findings.Methods Seventy-seven CSC patients who have undergone preoperative PET computed tomograms (PET/CT) are included in this study. Maximum PET-based tumor length (TL) and tumor width (TW) are determined using several auto-segmentation methods, and various thresholds of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are measured. The PET-based TL and TW are compared with maximum pathological length and width on the pathological specimen.Results Using a 30% threshold level for maximum uptake of TL (TL30%) and TW (TW30%) yield results that provide an optimal match with maximum pathological length (R = 0.81, p < 0.001) and width (R = 0.70, p < 0.001). TW30% was an independent factor for predicting pathological T3 or T4 stages (OR = 1.26, 95% CI = 1.07-1.47, p = 0.01). The receiver-operating characteristic curves show MTV at a fixed threshold of 40% maximum uptake (MTV40%), and TW30% achieved better correlation with the advanced pathological T stage. No associations with positive N stage were observed.Conclusion Pretreatment PET/CT is a useful tool for predicting the final pathological findings for CSC patients requiring surgical procedures. (C) 2013 Elsevier Ireland Ltd. All rights reserved.