Inactivation of the Nucleus Accumbens Core or Medial Shell Attenuates Reinstatement of Sugar-Seeking Behavior following Sugar Priming or Exposure to Food-Associated Cues
Inactivation of the Nucleus Accumbens Core or Medial Shell Attenuates Reinstatement of Sugar-Seeking Behavior following Sugar Priming or Exposure to Food-Associated Cues
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DOI：
10.1371/journal.pone.0099301
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发表时间：
2014-06-09
期刊：
影响因子：
3.7
通讯作者：
Pratt, Wayne E.
中科院分区：
文献类型：
--
作者：
Lin, Peagan;Pratt, Wayne E.
已知重新暴露于可口的食物或与食物相关的条件刺激可以在禁欲期后恢复食物寻求。在食物和药物寻求的范式中，核的核心和外壳对于恢复是重要的，尽管由于实验室之间范式的方法学差异，它们潜在的差异作用一直难以描述。本研究评估了暂时失活的核心或外壳的影响，引发和线索诱导的恢复觅食在相同的训练大鼠。失活无论是髓核的核心（实验1A; N = 10）或内侧壳（实验1B; N = 12）阻止引发诱导的恢复在一个等效的方式。类似地，核心或内侧壳的失活（实验2A和2B;各N = 11）也阻断了线索诱导的恢复，尽管也存在显著的治疗日X脑区域X药物顺序相互作用。具体而言，无论是第一次还是第二次试验，核心失活的大鼠在溶媒注射当天恢复了按压，而在第一天内侧壳失活的大鼠在试验第二天（接受溶媒时）没有显著恢复按压。育亨宾，而据报道，强大的药理学应激，是无效的诱导恢复在目前的压力诱导的恢复程序。这些数据表明，核的核心和外壳在恢复食物寻求启动和线索的反应中起着重要的作用。
Re-exposure to either palatable food or to conditioned stimuli associated with food is known to reinstate food-seeking after periods of abstinence. The nucleus accumbens core and shell are important for reinstatement in both food-and drug-seeking paradigms, although their potential differential roles have been difficult to delineate due to methodological differences in paradigms across laboratories. The present studies assessed the effects of temporary inactivation of the core or shell on priming-and cue-induced reinstatement of food-seeking in identically-trained rats. Inactivation of either the nucleus accumbens core (Experiment 1A; N = 10) or medial shell (Experiment 1B; N = 12) blocked priming-induced reinstatement in an equivalent manner. Similarly, inactivation of the core or medial shell (Experiments 2A & 2B; N = 11 each) also blocked cue-induced reinstatement, although there was also a significant treatment day X brain region X drug order interaction. Specifically, rats with core inactivation reinstated lever-pressing on the vehicle injection day regardless of whether that was their first or second test, whereas rats that had medial shell inactivation on the first day did not significantly reinstate lever-pressing on the second day of testing (when they received vehicle). Yohimbine, while a reportedly robust pharmacological stressor, was ineffective at inducing reinstatement in the current stress-induced reinstatement procedure. These data suggest that both the nucleus accumbens core and shell serve important roles in reinstatement of food-seeking in response to priming and cues.