Role of matrix metalloproteinases in intestinal inflammation
Role of matrix metalloproteinases in intestinal inflammation
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DOI：
10.1124/jpet.106.103465
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发表时间：
2006-09-01
影响因子：
3.5
通讯作者：
Radomski, Marek W.
中科院分区：
文献类型：
--
作者：
Medina, Carlos;Radomski, Marek W.
基质金属蛋白酶（MMP）及其内源性抑制剂，MMP的组织抑制剂（TIMP），是由胃肠道中的几种结构细胞产生的。MMPs和TIMPs之间的平衡对于肠道中的许多生理过程至关重要。然而，MMPs和TIMPs之间的不平衡在各种肠道炎症状况的病理生理学中起重要作用。我们回顾了MMP/TIMP系统在肠道炎症性疾病发病机制中的作用，以及使用恢复MMP/TIMP平衡的化合物的药理学观点。
Matrix metalloproteinases ( MMPs) and their endogenous inhibitors, tissue inhibitors of MMPs (TIMPs), are produced in the gastrointestinal tract by several structural cells. The balance between MMPs and TIMPs is essential for many physiological processes in the gut. However, imbalance between MMPs and TIMPs plays an important role in the pathophysiology of diverse intestinal inflammatory conditions. We reviewed the role of the MMP/TIMP system in the pathogenesis of intestinal inflammatory diseases and pharmacologic perspectives for the use of compounds that restore the MMP/TIMP balance.