DECREASE IN PLASMA TRYPTOPHAN AFTER TRYPTOPHAN-FREE AMINO-ACID MIXTURES IN MAN
DECREASE IN PLASMA TRYPTOPHAN AFTER TRYPTOPHAN-FREE AMINO-ACID MIXTURES IN MAN
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DOI：
10.1016/0024-3205(88)90013-6
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发表时间：
1988-01-01
期刊：
影响因子：
6.1
通讯作者：
TOFANETTI, O
中科院分区：
文献类型：
--
作者：
MOJA, EA;STOFF, DM;TOFANETTI, O
男性健康受试者，禁食12小时，摄入逐渐增加的含有固定比例的七种必需氨基酸（L-异亮氨酸11.5%、L-亮氨酸18.0%、L-赖氨酸13.1%、L-蛋氨酸18.0%、L-苯丙氨酸18.0%、L-苏氨酸8.2%、L-缬氨酸13.1%）的混合物，并且缺乏色氨酸。饮食导致血浆色氨酸迅速下降，其与摄入的氨基酸总量成正比。在给予最高剂量（36.6克）后，血浆色氨酸降至初始水平的最低约35%，并且在治疗后6小时仍显着降低。讨论了这种减少的机制及其潜在的临床相关性。
Male healthy subjects, fasting 12 hours, ingested increasing amounts of a mixture containing a fixed proportion of seven essential amino acids (L-isoleucine 11.5%, L-leucine 18.0%, L-lysine 13.1%, L-methionine 18.0%, L-phenylalanine 18.0%, L-threonine 8.2%, L-valine 13.1%) and lacking tryptophan. The diets produced a rapid fall in plasma tryptophan which was proportional to the total amount of the amino acids ingested. Following the highest dose administered (36.6 g) plasma tryptophan fell to a minimum of about 35% the initial level and remained markedly reduced at 6 hours after treatment. The mechanism of this decrease and its potential clinical relevance are discussed.