Factors Determining Colorectal Cancer: The Role of the Intestinal Microbiota.
Factors Determining Colorectal Cancer: The Role of the Intestinal Microbiota.
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DOI：
10.3389/fonc.2015.00220
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发表时间：
2015
影响因子：
4.7
通讯作者：
Olcoz JL
中科院分区：
文献类型：
--
作者：
Nistal E;Fernández-Fernández N;Vivas S;Olcoz JL
胃肠道，特别是结肠，拥有复杂的微生物群落，这对于维持体内平衡至关重要。然而，近年来，许多研究表明微生物群与结直肠癌 (CRC) 的发生有关，这种疾病被认为是西方世界的主要死亡原因。细菌对其发育的贡献机制很复杂，尚未完全了解。然而，越来越多的证据表明肠道微生物群与结直肠癌之间存在联系。肠道微生物通过不同的机制引起结直肠癌的发病和进展，例如诱导慢性炎症状态、干扰细胞周期调节的基因毒素的生物合成、有毒代谢物的产生或促饮食致癌化合物的杂环胺活化。尽管取得了这些进展，对人类和动物模型的进一步研究将进一步破译微生物群与结直肠癌之间的关系，并有助于开发基于微生物群操纵的替代疗法。
The gastrointestinal tract, in particular the colon, holds a complex community of microorganisms, which are essential for maintaining homeostasis. However, in recent years, many studies have implicated microbiota in the development of colorectal cancer (CRC), with this disease considered a major cause of death in the western world. The mechanisms underlying bacterial contribution in its development are complex and are not yet fully understood. However, there is increasing evidence showing a connection between intestinal microbiota and CRC. Intestinal microorganisms cause the onset and progression of CRC using different mechanisms, such as the induction of a chronic inflammation state, the biosynthesis of genotoxins that interfere with cell cycle regulation, the production of toxic metabolites, or heterocyclic amine activation of pro-diet carcinogenic compounds. Despite these advances, additional studies in humans and animal models will further decipher the relationship between microbiota and CRC, and aid in developing alternate therapies based on microbiota manipulation.