PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A
PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A
复制标题
DOI：
10.1128/jb.186.2.575-579.2004
复制
发表时间：
2004-01-01
影响因子：
3.2
通讯作者：
Miller, SI
中科院分区：
文献类型：
--
作者：
Moskowitz, SM;Ernst, RK;Miller, SI
分离出铜绿假单胞菌的自发多粘菌素抗性突变体。导致这种表型的突变被映射到类似于鼠伤寒沙门氏菌 PmrAB 的双组分信号转导系统。这些突变体的脂质 A 含有氨基阿拉伯糖，这是一种与多粘菌素抗性相关的诱导修饰。因此，铜绿假单胞菌具有响应环境条件而诱导对阳离子抗微生物肽的抗性的机制。
Spontaneous polymyxin-resistant mutants of Pseudomonas aeruginosa were isolated. The mutations responsible for this phenotype were mapped to a two-component signal transduction system similar to PmrAB of Salmonella enterica serovar Typhimurium. Lipid A of these mutants contained aminoarabinose, an inducible modification that is associated with polymyxin resistance. Thus, P. aeruginosa possesses a mechanism that induces resistance to cationic antimicrobial peptides in response to environmental conditions.