Accelerated Redox Reaction of Hydrogen Peroxide by Employing Locally Concentrated State of Copper Catalysts on Polymer Chain
Accelerated Redox Reaction of Hydrogen Peroxide by Employing Locally Concentrated State of Copper Catalysts on Polymer Chain
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DOI：
10.1002/marc.202100274
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发表时间：
2021-07-22
影响因子：
4.6
通讯作者：
Otsuka, Hidenori
中科院分区：
文献类型：
--
作者：
Osawa, Shigehito;Kitanishi, Kenichi;Otsuka, Hidenori
铜配合物作为氧化还原反应的催化剂，产生破坏生物分子的活性氧，因此被用于设计药物，包括抗肿瘤和抗菌药物。特别地，用于过氧化氢分解的催化反应是重要的，因为它包括产生高毒性羟基自由基的过程，即，芬顿反应考虑到多铜/过氧化氢物质是氧化还原反应的重要中间体，本文设计了在侧链中具有铜络合物的聚合物，以通过建立铜络合物的局部浓缩状态来促进中间体的形成。该聚合物增加了它们对过氧化氢分解的催化活性，并促进活性氧的产生，最终导致更高的抗菌活性。这揭示了在聚合物上构建局部集中状态的催化剂对具有少量过渡金属的药物设计的优点。
Copper complexes act as catalysts for redox reactions to generate reactive oxygen species that destroy biomolecules and, therefore, are utilized to design drugs including antitumor and antibacterial medicines. Especially, catalytic reaction for hydrogen peroxide decomposition is important because it includes the process for generating highly toxic hydroxyl radical, i.e., Fenton-like reaction. Considering that multicoppers/hydrogen peroxide species are the important intermediates for the redox reaction, herein a polymer having copper complexes in the side chains is designed to facilitate the formation of the intermediates by building locally concentrated state of the copper complexes. The polymer increases their catalytic activities for hydrogen peroxide decomposition and promotes reactive oxygen species' generation, eventually leading to higher antibacterial activity. This reveals the virtue of building a locally concentrated state of catalysts on polymers toward drug design with low amounts of transition metals.