Radiation protraction schedules for low-grade gliomas: a comparison between different mathematical models
Radiation protraction schedules for low-grade gliomas: a comparison between different mathematical models
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DOI：
10.1098/rsif.2019.0665
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发表时间：
2019-12-01
影响因子：
3.9
通讯作者：
Belmonte-Beitia, J.
中科院分区：
文献类型：
--
作者：
Budia, I.;Alvarez-Arenas, A.;Belmonte-Beitia, J.
我们优化放疗（RT）给药策略治疗低级别胶质瘤。具体来说，我们考虑了不同的肿瘤生长规律，包括有和没有空间效应。在每种情况下，我们都找到了最佳治疗方法，即最大化虚拟低级别胶质瘤患者的总生存时间，该患者的肿瘤根据所检查的生长规律进展。我们发现，一种极端的延长治疗策略，相当于大大延长RT会议之间的时间间隔，可能导致更好的肿瘤控制。我们的结果的临床意义也提出。
We optimize radiotherapy (RT) administration strategies for treating low-grade gliomas. Specifically, we consider different tumour growth laws, both with and without spatial effects. In each scenario, we find the optimal treatment in the sense of maximizing the overall survival time of a virtual low-grade glioma patient, whose tumour progresses according to the examined growth laws. We discover that an extreme protraction therapeutic strategy, which amounts to substantially extending the time interval between RT sessions, may lead to better tumour control. The clinical implications of our results are also presented.