Potential for Stem Cell-Based Periodontal Therapy.
Potential for Stem Cell-Based Periodontal Therapy.
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DOI：
10.1002/jcp.25067
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发表时间：
2016-01
影响因子：
5.6
通讯作者：
Intini G
中科院分区：
文献类型：
--
作者：
Bassir SH;Wisitrasameewong W;Raanan J;Ghaffarigarakani S;Chung J;Freire M;Andrada LC;Intini G
牙周病非常普遍，并与几种全身性疾病有关。牙周治疗的目标是阻止疾病的发展，并再生受损的组织。然而，由于牙周组织是一个由骨、牙骨质和牙周膜等不同组织组成的复杂结构，实现完整的、有功能的牙周再生是具有挑战性的。干细胞的可塑性和分化为不同细胞系的能力可能成为牙周再生的有效治疗手段。这篇综述介绍并批判性地分析了以干细胞为基础的牙周组织再生治疗的现有信息，并提出了开发更有效的治疗方案的新途径。
Periodontal diseases are highly prevalent and are linked to several systemic diseases. The goal of periodontal treatment is to halt the progression of the disease and regenerate the damaged tissue. However, achieving complete and functional periodontal regeneration is challenging because the periodontium is a complex apparatus composed of different tissues, including bone, cementum, and periodontal ligament. Stem cell-based regenerative therapy may represent an effective therapeutic tool for periodontal regeneration due to their plasticity and ability to differentiate into different cell lineages. This review presents and critically analyzes the available information on stem cell-based therapy for the regeneration of periodontal tissues and suggests new avenues for the development of more effective therapeutic protocols.