Extraction, confirmation, and screening of non-target compounds in silicone rubber teats by purge-and-trap and SPME combined with GC-MS
Extraction, confirmation, and screening of non-target compounds in silicone rubber teats by purge-and-trap and SPME combined with GC-MS
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吹扫捕集、SPME 结合 GC-MS 提取、确认和筛选硅橡胶奶嘴中的非目标化合物
DOI：
10.1016/j.polymertesting.2016.09.021
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发表时间：
2016-12
期刊：
影响因子：
5.1
通讯作者：
栗真真
中科院分区：
文献类型：
--
作者：
封棣;杨慧敏;戚冬雷;栗真真
作为食品接触材料，硅橡胶奶嘴的安全性非常重要。对硅橡胶奶嘴中非目标化合物的分析是类似高分子材料安全性评价和预警机制的前瞻性工作。本研究采用两种“绿色”分析方法，分别采用吹扫捕集法和固相微萃取法提取30个硅橡胶乳头样品中的非目标化合物。采用气相色谱-质谱联用技术，结合质谱库匹配、保留指数（RI）和标准品确证3种定性方法，共分离鉴定了140种化合物。色谱峰面积归一化用于近似各组分的相对含量。建立了包含12类140种化合物的数据库。为了确定可能迁移和危害婴儿健康的值得注意的化合物，所有化合物均通过基于检出率、RI和相对含量的三步筛选过程进行筛选。最后，53个选定的化合物包括烷烃，硅氧烷，芳烃，醛，三甲基硅烷醇，丁基羟基甲苯，N，N-二丁基甲酰胺和苯并噻唑。鉴于这些化合物检出率较高、相对含量较高或存在潜在毒性，应进一步开展安全性评价。
As a food contact material, the safety of silicone rubber teats for infants is very important. This analysis of non-target compounds in silicone rubber teats is a prospective work on the safety evaluation and early warning mechanism for similar polymer materials. In this study, two “green” analytical approaches were applied to extract non-target compounds in 30 silicone rubber teats based on the purge-and-trap method and solid phase microextraction. A total of 140 extracted compounds were separated and identified by gas chromatography-mass spectrometry, coupled with three qualitative methods, namely, matching with the mass spectra library, retention index (RI) and standard confirmation. Chromatographic peak area normalization was used to approximate the relative content of each component. A database containing 140 compounds in 12 categories was established. To identify the noteworthy compounds that could migrate and endanger infant health, all compounds were filtered by a three-step screening process based on the detection rate, RI and relative content. Finally, the 53 selected compounds included alkanes, siloxanes, aromatics, aldehydes, trimethylsilanol, butylated hydroxytoluene,N,N-dibutylformamide and benzothiazole. Given their higher detection rate, higher relative content or potential toxicity, these compounds should be further investigated for safety evaluation.
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DOI：
10.1080/02652039809374601
发表时间：
1998
期刊：
Food additives and contaminants
影响因子：
--
作者：
J. Linssen;L. Rijnen;A. Legger-Huiysman;J. Roozen
通讯作者：
J. Linssen;L. Rijnen;A. Legger-Huiysman;J. Roozen
影响因子：
4.8
作者：
Curran, Katherine;Underhill, Mark;Strlic, Matija
通讯作者：
Strlic, Matija
影响因子：
8.8
作者：
Murat, Chloe;Gourrat, Karine;Cayot, Nathalie
通讯作者：
Cayot, Nathalie
影响因子：
8.8
作者：
J. Velicogna;Ellyn E Ritchie;J. Princz;Marie-Eve Lessard;R. Scroggins
通讯作者：
J. Velicogna;Ellyn E Ritchie;J. Princz;Marie-Eve Lessard;R. Scroggins
影响因子：
8.9
作者：
Wenjun Hong;Hongliang Jia;Cheng-Chung Liu;Zi-Feng Zhang;Yeqing Sun;Yi-Fan Li
通讯作者：
Wenjun Hong;Hongliang Jia;Cheng-Chung Liu;Zi-Feng Zhang;Yeqing Sun;Yi-Fan Li