Effect of glycine in streptozotocin-induced diabetic rats
Effect of glycine in streptozotocin-induced diabetic rats
复制标题
DOI：
10.1016/s1532-0456(03)00046-2
复制
发表时间：
2003-04-01
影响因子：
3.9
通讯作者：
Carvajal-Sandoval, G
中科院分区：
文献类型：
--
作者：
Alvarado-Vásquez, N;Zamudio, P;Carvajal-Sandoval, G
糖尿病患者对葡萄糖的不充分利用有利于多种代谢改变，这些代谢改变在糖尿病慢性并发症的生理病理中起相关作用。链脲佐菌素诱导的糖尿病大鼠每天服用甘氨酸（130 mM为最佳浓度）或牛磺酸（40 mM），持续6个月。以未治疗的糖尿病大鼠为对照组。血糖、总胆固醇、甘油三酯、糖化血红蛋白在诱发糖尿病后定期测定。治疗6个月后处死大鼠，进行组织学分析。接受甘氨酸或牛磺酸治疗的糖尿病组的葡萄糖、总胆固醇、甘油三酯和糖化血红蛋白浓度明显低于糖尿病对照组(P
Inadequate utilization of glucose in diabetes mellitus favors diverse metabolic alterations that play a relevant role in the physio-pathology of chronic complications of this disease. Streptozotocin-induced diabetic rats were treated daily with glycine (130 mM as optimal concentration) or taurine (40 mM) for six months. Groups of diabetic rats without treatment were used as controls. Glucose, total cholesterol, triacylglycerol, and glycated hemoglobin were determined periodically after inducing diabetes. Rats were killed after 6 months of treatment and histological analyses were performed. Diabetic groups that received glycine or taurine showed significant lower concentrations of glucose, total cholesterol, triacylglycerol, and glycated hemoglobin than diabetic control rats (P